Lutein levels linked to better memory in adults: Study

By Stephen Daniells

- Last updated on GMT

Lutein for dietary supplements is extracted from marigolds. Image © Getty Images / PaulPaladin
Lutein for dietary supplements is extracted from marigolds. Image © Getty Images / PaulPaladin
Serum levels of the carotenoid lutein are linked to improved memory function in overweight and obese adults, but other carotenoids are not, says a new study from the University of Illinois at Urbana-Champaign.

Data published in the journal Nutrients​ indicated that higher serum levels of lutein were associated with accuracy in object binding and inversely related to misplacement error.

“Our results revealed that serum lutein was significantly related to two metrics of relational memory performance even after adjusting for significant covariates. While this study was correlational, it lays the groundwork for subsequent research in this area,”​ wrote the scientists, led by Naiman Khan, PhD, RD.

Lutein and brain health

Lutein is most commonly associated with eye health, but numerous studies with data from primates, children, middle-aged people, and the elderly now support the importance of lutein in brain health. 

Data from pediatric brain tissue studies have shown that about 60% of the total carotenoids in the pediatric brain tissue is lutein, and yet NHANES data show that lutein is only about 12% of the carotenoids in the diets, so there appears to be a preference for lutein in the brain (Vishwanathan et al. J Pediatr Gastroenterol Nutr.​ 2014).

A 2017 study in rhesus macaques found that enriching infant formula with lutein led to selectively increased levels of the carotenoid in the infant brain, with the highest amounts in the visual processing center, the occipital cortex (Jeon et al., Nutrients​).

The new study assessed dietary carotenoid intakes and serum carotenoid levels from 94 adults aged between 25 and 45. The participants also underwent relational memory tests.

After adjusting the results to factor in age, sex, and BMI, only serum lutein was associated with specific types of memory performance, said the researchers.


Healthy Aging 2019

Join NutraIngredients-USA for a special online event on May 29 discussing the healthy aging category: The NutraIngredients-USA’s Healthy Aging Online Conference will bring together industry experts to explore the consumer demands and expectations, the demographic targets, and the ingredients, products, and brands driving this trend.

For more information, please click HERE​.

Commenting on the potential mechanism(s) of action, the researchers noted that this may be linked to lutein’s anti-oxidant and anti-inflammatory activity.

“Participants with overweight or obesity are more susceptible to oxidative and inflammatory stress due to the higher levels of chronic inflammation associated with excess adipose tissue,” ​they wrote. “Inflammation and oxidative stress can be mitigated by fruit and vegetable intake, foods that are often rich in carotenoids. Inflammation is detrimental to hippocampal function, specifically by inhibiting long term potentiation, the molecular mechanism for memory formation. In the retina, lutein is protective against age-related macular degeneration by reducing oxidative stress. Thus, we hypothesize that lutein may play a similar role in the hippocampus.”

Dr Khan and his co-workers called for that future intervention studies to assess carotenoids in the macula and serum in order to better understand this relationship, particularly in overweight or obese people.

Source: Nutrients
2019, 11​(4), 768; doi: 10.3390/nu11040768
“Serum Lutein is related to Relational Memory Performance”
Authors: C.N. Cannavale et al.

Related news

Show more

Related products

show more

How to soothe pet with natural ingredients

How to soothe pet with natural ingredients

Ingredia SA | 06-Mar-2023 | Product Presentation

Stress rises for your pet, which may lead to destructive behaviors, barking, accidents in the house, skin, or gastrointestinal problems.

Magtein Application Data for Product Development

Magtein Application Data for Product Development

AIDP, Inc | 01-Mar-2023 | Application Note

Brain health and mental wellness are intertwined. Brain health products are no longer just for memory and focus and have expanded into related health segments...

Related suppliers

Follow us


View more