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AlphaWave® L-Theanine shows significant stress reduction benefits in a new clinical study

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Stress is a complex life occurrence essential for survival and goal-achievement, but is damaging in excess. Being over-stressed is a risk factor for health problems such as mental health issues, substance abuse, and high BP. In some cases stress can even dampen the immune system, increasing susceptibility to both colds and common infection. Even moderate stress levels can negatively affect sleep patterns or other factors of well-being.

Because stress-levels are currently high, and drug treatments for managing stress can result in undesirable side effects, there is a strong demand today for a safe supplement that reduces stress levels, without these effects. AlphaWave has been a leading ingredient of choice in this field for over ten years and is now supported by two direct clinical studies.

The new study: a brief summary:

Study conducted by: KGK Science Inc.

Published by Neurology and Health, September 2021

‘A randomized, triple-blind, placebo-controlled, crossover study to investigate the efficacy of a single 200mg dose of AlphaWave® L-Theanine on stress in a healthy adult population.’

The objective of this study, thought to be the first to investigate the effects of L-theanine in a population of healthy adults reporting moderate levels of stress, was to investigate the efficacy and safety of AlphaWave L-Theanine both on frontal alpha power and salivary cortisol levels in healthy, moderately stressed adults. Increases in brainwave alpha power indicate greater relaxation without drowsiness, and salivary cortisol is also an objective measure of stress levels.


The 16 subjects (cross-over design), ranging from age 16 to 60, were administered a 200mg single dose of AlphaWave L-Theanine and the response to an acute stress model was investigated.  This study was conducted during the global SARS-CoV-2 pandemic, which has had a rapid and significant effect on both physical and mental health around the world. In the study, the single dose of AlphaWave L-Theanine significantly increased frontal region alpha power, and significantly reduced salivary cortisol levels, compared to placebo. These changes are indicative of relaxation in the brain and demonstrate a calming response in healthy adults between 19 and 60 years of age.

The study concludes that:​ ‘In conclusion, a 200mg dose of AlphaWave L-Theanine improved physiological indicators of stress in response to the MAT test compared to the placebo, including frontal region alpha power and salivary cortisol. A 200mg dose of AlphaWave L-Theanine was found to be safe and well tolerated and should be considered as a nutraceutical supplement to manage acute stress.’

To view complete study:


The first AlphaWave Clinical study

Conducted at: The Wellington Sleep Investigation Centre, University of Otego, Wellington, New Zealand.

‘The Effects of AlphaWave ​L-Theanine on Relaxation, Clarity and Cognitive Function: a Human Study w/20 Subjects: a randomized, double blind, placebo controlled study ’

Study design and method:

A randomized, double blind, placebo controlled study assessed relaxation after a 200mg dose of AlphaWave through measurement of alpha brainwave changes and responses to stress tests. It also assessed changes in heart rate as an indication of stress level. Twenty subjects (10 male and 10 female), aged between 21 and 47 years, were tested for the effects of AlphaWave ​L-Theanine or placebo.


Consumption of 200mg of AlphaWave L-Theanine produced significant changes over time as compared to placebo on all the variable outcomes assessed in this investigation. For example, AlphaWave L-Theanine showed a positive effect over time on the tonic alpha power, that measures relaxed wakefulness, whereas the placebo had negative effects. Although the values for anxiety/tension were low, they decreased over time for both groups, and the decrease in AlphaWave group was greater. The group consuming AlphaWave®​ also displayed reduced fatigue.

In addition, AlphaWave ​L-Theanine significantly reduced the heart rate compared with placebo over the time period of the study. This was a further indication of the actual stress reduction effect of AlphaWave L-Theanine.

AlphaWave is GRAS Affirmed​, and ideal for supplement and beverage use

  • Highly purified and standardized to 98% L-Theanine
  • Excellent tableting and encapsulation qualities
  • GRAS Affirmed
  • Dissolves into tasteless and odorless solution for beverage use
  • Proprietary manufacturing process infringes no patents
  • Inventoried and supplied through ENI’s NSF certified cGMP facility

Cal Bewicke, CEO of Ethical Naturals states: ‘We have supplied AlphaWave L-theanine to the industry for about ten years now, and it has been extraordinary to see the popularity of this product grow through the brands that offer it to consumers. It seems that the calming experiential nature of the product, as well as the science behind it, are what is behind its success. We’re very pleased now to deliver one more level of scientific support to AlphaWave’.

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