Antioxidant rich diet linked to lower diabetes risk in women: Study

By Tim Cutcliffe

- Last updated on GMT

Antioxidant rich diet linked to lower diabetes risk in women: Study

Related tags Antioxidant capacity Antioxidant Nutrition

Consuming a diet rich in antioxidant foods is associated with a reduction in risk of type-2 diabetes (T2D) in middle-aged women, reports a new study in Diabetologia.

Women with the highest quintile of dietary antioxidant intake, measured by total antioxidant capacity (TOC), reduced their risk of T2D by 27%, found researchers from the Health Across Generations (HAG) Team, Centre of Research in Epidemiology and Population Health, Villejuif, France (an INSERM team).

Total antioxidant capacity (TOC) is an index which estimates the aggregated antioxidant capacity from the sum of all the individual antioxidant components in the diet.

“Our findings suggest that the TOC may play an important role in reducing the risk of T2D in middle-aged women,” ​wrote first author Francesca Romana Mancini.  

The development of T2D may involve oxidative stress, recent evidence has suggested.  A diet containing fruit, vegetables and beverages including tea contains a variety of compounds with antioxidative properties.

In this study, “the food groups that contributed the most to the TOC were fruit (23%), vegetables (19%), alcoholic beverages (15%) and hot beverages such as tea, chicory and hot chocolate (12%),” ​wrote the researchers.

“In our population study, women with higher levels of total antioxidant capacity (measured excluding the contribution of coffee), were characterised by a high consumption of fruit and vegetables and tea, which are known to be rich in antioxidant compounds,”​ they added.

The T2D risk reduction benefit of a higher antioxidant intake plateaued at a TOC level of 15 millimoles/ day (mmol/d), the team reported.

Results build on earlier findings

Earlier research had identified an inverse relationship between TOC and components of metabolic syndrome. However, this is the first study to examine the relationship of TOC with T2D risk directly.  Previous studies had also shown that intake of various forms of vitamin E, but not vitamin C, flavonoids or lycopene, had an association with lower T2D risk.

'This work complements our current knowledge of the effect of isolated foods and nutrients, and provides a more comprehensive view of the relationship between food and type 2 diabetes'​ explained lead researcher Guy Fagherazzi, in charge of the diabetes research and complications programme in the Health across Generations team.

“This link persists after taking into account all the other principal diabetes risk factors: smoking, education level, hypertension, high cholesterol levels, family history of diabetes and, above all, BMI, the most important factor”​, commented Mancini.

Perhaps surprisingly, the researchers excluded coffee from the calculation of TOC. This was because coffee has such a high antioxidant content, that it would have driven the association with T2D on its own, distorting the results. Furthermore, inclusion of coffee may have introduced confounding due to its known associations with smoking, high alcohol consumption and stressful lifestyle.

Study details 

The study population comprised of 64,223 French women from the E3N-EPIC cohort aged between 40-65. The participants were free of diabetes and heart disease at baseline, and were followed for 15 years between 1993-2008. Dietary intake from a questionnaire completed by the subjects was used in conjunction with an Italian database (providing the antioxidant capacity of different foods) to calculate TOC.

“We have shown that an increased intake of antioxidants can contribute to a reduction in diabetes risk.” ​However, the mechanisms are not fully understood. “We know that these molecules counterbalance the effect of free radicals, which are damaging to cells, but there are likely to be more specific actions in addition to this, for example an effect on the sensitivity of cells to insulin. This will need to be confirmed in future studies,”​ concludes Mancini.

Source: Diabetologia
Published online, doi: 10.1007/s00125-017-4489-7
“Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort”
 Authors: Francesca Romana Mancini, Guy Fagherazzi et al

Related topics Research Antioxidants/carotenoids

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1 comment

What about reversing diabetes2l?

Posted by ThomasTurk,

Those on a zero grain and zero sugar diet reversed diabetes 2in 2-4 weeks. But, aren't we advised to eat grains up to 11X a day, and even recommended 6 teaspoons of sugar daily.. in the Agric. Dept Healthy Eating guidelines? Sure we are.. but from where did these guidelines originate? In the 1960s, Harvard Med School were doing a sugar study. The Sugar Industry bribed the Profs. who then rewrote the study, blaming bad fats for most ills. The head of that Sugar Industry team went on to join the US Agric. Dept and was tasked with writing up the calories, cholesterol, food groups, food pyramid, RDAs baloney that now misinforms us. (From Sugar Industry Docs. discovered by a team from the U of San Francisco).

Grains? All grains are high in lectin plant phenols, chemicals that desensitize cell membranes to insulin, causing insulin over production. Grains are also high in leptin plant hormones that interrupt signaling between the liver and pancreas, causing insulin disruptions. These 2 cause obesity and diabetes2.

Wheat and most other grains raise blood sugar. A slice of organic whole wheat bread raises blood sugar more than a candy bar.

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