Is ATP + HMB an ideal combination to create a ‘new and untapped category in sports’?


- Last updated on GMT

Is ATP + HMB an ideal combination to create a ‘new and untapped category in sports’?

Related tags Adenosine triphosphate

Supplements containing a combination of the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) and adenosine-triphosphate (ATP) may boost lean body mass and strength, says a new study.

HMB free acid alone was found to enhance strength and power and prevent declines in performance, while ATP alone boosted strength and power, and improve fatigue, according to findings being presented at the International Society of Sports Nutrition Annual Meeting in Colorado Springs, CO.

Prof. Jacob Wilson from the Human Performance and Sports Nutrition Laboratory at The University of Tampa, and lead researcher on the study, told us: “Theoretically the combination of the two might therefore be synergistic in nature.  This is exactly what we found. 

“After 12 weeks of training with ATP, HMB free acid, or both, the combination group demonstrated synergistic gains in the most extreme performance activities suggesting that these two may be an ideal combination."

A new & untapped category in sports

Larry Kolb, president of TSI USA (co-sponsors of the study), said the research establishes the clear performance benefits with oral supplementation of PEAK ATP at a higher dose.

“As a result, TSI has tremendous opportunities to create a new and untapped category in sports, Muscular Excitability. We look forward to continuing our work with Dr. Wilson and other leading researchers to pioneer the benefits offered by oral ATP."

Study details

Dr. Ralf Jäger, president of Increnovo LLC and co-researcher on the study, explained that only limited research exists that examined HMB in highly trained athletes, particularly under high intensity extreme training regimens. In addition, there is a lack of long-term research of oral ATP administration investigating its potential benefits on power and strength due to its vasodilating effects and increases in muscular excitability, he said.

The new study used powerful athletes during one of the most intense training regimens found in the literature. Subjects were randomly assigned to receive either 3g per day of HMB in the free acid form (Metabolic Technologies), 400mg per day of Peak ATP (TSI USA), or a combination of the two.

Results showed that HMB not only enhanced hypertrophy, strength, and power, but also prevented declines in performance in over-trained athletes. ATP increased strength and power and improved fatigue.

“The combination of ATP and HMB showed synergistic effects and seems to be a supplement extremely useful to those pushing their limits,”​ said Dr Jäger.

Dr Shawn Baier, COO of Metabolic Technologies (co-sponsor of the study), welcomed the study as “critical for the understanding of the proper use and efficacy of this new delivery form of HMB. 

“As we continue our long-standing commitment to quality research with the help of experts in their field of study, such as Dr. Wilson, we are discovering the added benefits and synergies of combining efficacious compounds like ATP and HMB."  

Source: International Society of Sports Nutrition Annual Meeting
“Effects of 12 Weeks of Beta-Hydroxy-Beta-Methylbutyrate Free Acid, Adenosine Triphosphate, or a Combination on Muscle Mass, Strength, and Power in Resistance Trained Individuals”
Authors: R.P. Lowery, J. Joy, J.A. Rathmacher, S.M. Baier, J.C. Fuller, R. Jäger, S.M.C. Wilson, J.M Wilson

Related topics Research Energy Sports nutrition

Related news

Show more

Related products

show more

Boost Your Sports Nutrition Solution with Peptan

Boost Your Sports Nutrition Solution with Peptan

Content provided by Rousselot | 13-Nov-2023 | White Paper

Athletes are prioritizing their well-being and seeking nutritional solutions to optimize recovery, making it an indispensable aspect of their performance.

New Study for Female Athletes

New Study for Female Athletes

Content provided by Gencor | 17-Oct-2023 | Product Brochure

In a recent clinical trial backing its ingredient Libifem® for improved muscle strength, power, endurance and body composition with a females-only popluation...

Related suppliers



Posted by Angelo Bruno,

It should be said that measuring body composition using DXA is an art. If it's done by a student rather than an experienced technology, the results are likely to be dubious. But even so, an 8.5 kg increase in lean body mass is unbelievable. I say BULLSHI!
For the record, Lowery's study was financed by Metabolic Technologies, the company that discovered the muscle enhancing effect of HMB and patented the substance too.

Report abuse

Organic chemistry anyone?

Posted by Stephen Cherniske,

Since no one has demonstrated how or if oral ingestion of ATP increases muscle strength, size or quality, this study has to be viewed as preliminary. MOA data on HMB, on the other hand is well understood and widely accepted.

Report abuse

Follow us


View more