Compound Solutions goes through self-affirmed GRAS process for energy ingredient Dynamine

By Adi Menayang

- Last updated on GMT

Getty Images / Global Stock
Getty Images / Global Stock

Related tags Energy Nootropic Cognitive function

Dynamine, a branded form of methylliberine distributed by California-based ingredient company Compound Solutions, has gone through the self-affirmed Generally Recognized as Safe (GRAS) process to validate its safety.

The company described the ingredient as a “new rapid-onset clean energy and focus ingredient…poised to disrupt the category” ​in a press release announcing its self-affirmed GRAS status.

The ingredient is a nature-identical compound of a purine alkaloid naturally occurring in kucha tea, and Compound Solutions is positioning it for use in energy drinks, pre-workouts, and nootropics targeting athletes, gamers, and more.

According to the company, it is the first and so far the only one that has conducted a clinical study on humans using the standardized methylliberine Dynamine. Matt Titlow, CEO of Compound Solutions, told us that the studies have not been published in journals yet, but they have been presented as abstracts​ at the International Society of Sports Nutrition’s conferences in 2018 and 109.

“This, along with two other ongoing efficacy studies, will be completed and submitted for publication in August or September. They’ll publish in early 2020,”​ he added.

The self-affirmed GRAS process entailed a review by an independent expert panel, selected by Compound Solutions, to review the ingredient's safety data. Companies may choose to notify the Food and Drug Administration (FDA) about the review's results, to which the agency may reply with a no objections letter.

Formulating using Dynamine

Titlow said that the ingredient is a powder, and it is bitter, though not as bitter as TeaCrine, a branded form of energy ingredient theacrine in Compound Solution’s portfolio.

“So, 100 mg can easily be incorporated into a 16oz energy drink, for example,” without ​the bitterness affecting the product’s palatability, he said. “We also have a 40% coated material for pre-workouts and other powder products in which the formulator wants zero bitterness.”

The main differences between Dynamine and the other energy ingredient in Compound Solution’s line up, TeaCrine, is that Dynamine has a quicker onset of action, Titlow explained. “Anecdotally, about 20 minutes versus TeaCrine’s 45 minutes,” ​he said.

READ MORE: Study vets TeaCrine dose, finds positive results on energy, focus and mood

READ MORE: TeaCrine plus caffeine may help maintain energy and offer cognitive benefits: Soccer Study

Additionally, Dynamine may provide larger increases in energy in combination with caffeine, and Dynamine may last a shorter period of time (three hours versus TeaCrine’s five to six hours).

“It should also be noted that Dynamine and TeaCrine work exceptionally well together,”​ Titlow said. “For example, caffeine, TeaCrine, Dynamine provide a quick onset of action, then continue to provide energy, motivation and focus for more than five hours.”

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