Daily collagen supplementation may protect against cartilage loss for joint health, rodent study suggests

By Adi Menayang contact

- Last updated on GMT

Daily collagen supplementation might contribute to joint health. ©iStock
Daily collagen supplementation might contribute to joint health. ©iStock

Related tags: Chondroitin sulfate, Osteoarthritis

Daily oral consumption of hydrolysed type 1 collagen may protect joints with osteoarthritis from further cartilage loss, as well as deliver anti-inflammatory properties to injured joints, according to a new mouse study.

The researchers, funded by manufacturer Rousselot BVBA​, found that in 12 weeks, mice supplemented daily with a higher dose of collagen before the operation to simulate osteoarthritis lost significantly less cartilage than lower-dose supplemented mice.

These results put collagen side-by-side with other nutraceutical ingredients like chondroitin and glucosamine as a non-drug preventive solution for osteoarthritis.

But researchers in this current study argued that results have been mixed, and as the global medical bill for lower extremity osteoarthritis exceeds $350bn annually​, the development of therapeutic strategies that offer protective and / or regenerative capability is a critical unmet need and central pursuit in the osteoarthritis field,”​ they wrote in their study​, published in the journal PLOS ONE​.

Study design and supplementation

To investigate the hypothesised joint-protective impact of long-term collagen use, mice were supplemented with the collagen for a one-month pre-treatment period, followed by a meniscal-ligamentous injury to simulate post-traumatic osteoarthritis on the left leg, and a sham ‘operation’ on the right as control (where no joints were manipulated).

The supplementation, Rousselot’s bovine-origin hydrolysed type 1 collagen, branded Peptan B2000, was incorporated into hazelnut and chocolate cream (Nutella) for the mice to eat. Two doses were selected, a low dose (3.8mg) and a high dose (38mg) — the high dose was the body weight-adjusted mouse equivalent to the 7.4g/day recommended human dose.

Mice administered hydrolysed type 1 collagenn were chondroprotected’

While there were no discernable cartilage effects in the sham / normal joints, at early and later time points in the development of osteoarthritis, mice administered Peptan were chondroprotected, particularly at 12 weeks post-injury, the researchers found.

Overall, these results provide the first indication that dietary supplementation with (hydrolyzed type 1 collagen) could be protective in the development and progression of post-traumatic osteoarthritis,”​ the researchers wrote.

Source: PLOS Journal


"Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis​"

Authors: Qurratul-Ain Dar, et al

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1 comment

Vegetarian source collagen peptide

Posted by Sandeep Saluja,

I am a clinician and many of my patients refuse collagen on grounds that is of animal source.Since it is the peptide which is biologically active would it not be possible to have the peptide synthesised from vegetarian source.Is anyone doing it?

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