The researchers, funded by manufacturer Rousselot BVBA, found that in 12 weeks, mice supplemented daily with a higher dose of collagen before the operation to simulate osteoarthritis lost significantly less cartilage than lower-dose supplemented mice.
These results put collagen side-by-side with other nutraceutical ingredients like chondroitin and glucosamine as a non-drug preventive solution for osteoarthritis.
But researchers in this current study argued that results have been mixed, and as the global medical bill for lower extremity osteoarthritis exceeds $350bn annually, “the development of therapeutic strategies that offer protective and / or regenerative capability is a critical unmet need and central pursuit in the osteoarthritis field,” they wrote in their study, published in the journal PLOS ONE.
Study design and supplementation
To investigate the hypothesised joint-protective impact of long-term collagen use, mice were supplemented with the collagen for a one-month pre-treatment period, followed by a meniscal-ligamentous injury to simulate post-traumatic osteoarthritis on the left leg, and a sham ‘operation’ on the right as control (where no joints were manipulated).
The supplementation, Rousselot’s bovine-origin hydrolysed type 1 collagen, branded Peptan B2000, was incorporated into hazelnut and chocolate cream (Nutella) for the mice to eat. Two doses were selected, a low dose (3.8mg) and a high dose (38mg) — the high dose was the body weight-adjusted mouse equivalent to the 7.4g/day recommended human dose.
‘Mice administered hydrolysed type 1 collagenn were chondroprotected’
While there were no discernable cartilage effects in the sham / normal joints, at early and later time points in the development of osteoarthritis, mice administered Peptan were chondroprotected, particularly at 12 weeks post-injury, the researchers found.
“Overall, these results provide the first indication that dietary supplementation with (hydrolyzed type 1 collagen) could be protective in the development and progression of post-traumatic osteoarthritis,” the researchers wrote.
Source: PLOS Journal
Authors: Qurratul-Ain Dar, et al