Clinical Trial

Ketone supplementation for healthy aging in the elderly: Preparing for TAKEOFF

03-Nov-2023 By Asia Sherman

The Buck Institute for Research on Aging is getting ready to launch the first-ever clinical trial on the effects of ketone supplementation on frailty after receiving a $3.5 million grant from the National Institutes of Health.

Radicle Science: Blazing the trail to accessibility

17-Jul-2023 By Danielle Masterson

Improving the cost and speed of clinical trials has been a long time coming. While plenty of hurdles remain, Radicle Science is doing it – all the while maintaining scientific rigor and bettering the generalizability of the findings.

FDA updates clinical trials guidance to align with ICH: What’s the impact for supplements?

14-Jun-2023 By Stephen Daniells

The US Food and Drug Administration recently released a draft guidance with updated recommendations for good clinical practices (GCPs) aimed at modernizing the design and conduct of clinical trials.

Accreditation board aims to enhance scientific credibility of supplements

19-May-2023 By Olivia Haslam

A nonprofit accreditation body, Empowered by Evidence (EBE), gave an impassioned presentation to the audience of Vitafoods 2023, calling for companies to promote better standards in industry science.

Novel mobile app gives real-world support for hydrolyzed cartilage matrix’s joint health benefits

18-May-2023

Daily oral Colartix hydrolyzed cartilage matrix (HCM) supplementation may improve joint discomfort in a wide variety of people, according to real-world data collected using a novel mobile app.

FANCL’s Calolimit CVD and diabetes supplement backed by two new clinical trials

17-Mar-2020 By Guan Yu Lim

A FANCL-funded RCT study has discovered that the ingestion of tea flower extract, mulberry leaf extract, and chitosan could reduce postprandial blood glucose and triglyceride levels in healthy subjects.

Probiota Asia 2019

Probiotic research booming in Asia with China and Iran leading the charge

23-Oct-2019 By Tingmin Koe

A growing number of clinical studies focusing on probiotics is seen in Asia, with China and Iran seeing exponential increase in recent years, according to an International Probiotics Association-backed review.

First CBD trial on PTSD to drive research and NPD for Bod Australia's nutraceutical arm

03-Jul-2019 By Cheryl Tay

Australia's first trial to test the effects of CBD (cannabidiol) oil on individuals suffering from post-traumatic stress disorder (PTSD) will feature Bod Australia's proprietary CBD oil, MediCabilis.

Collaborating for cognitive gains: DSM-Senescence link-up aims for huge public health impact

11-Jun-2019 By Cheryl Tay

DSM has entered a regional agreement with SLS Nutraceuticals, a subsidiary of biotechnology company Senescence Life Sciences, in a bid to improve brain health across all life stages in the Asia-Pacific region.

A look at brain waves after pre-workout supplement ingestion suggests it may increase alertness

14-May-2018 By Adi Menayang

A supplement with an ingredient combo including L-theanine, beta-alanine, and theacrine may help users increase brain alertness, researchers concluded after a placebo-controlled clinical trial.

Aged garlic extract supplementation may benefit health of adults with obesity

09-May-2018 By Adi Menayang

Obese adults supplemented with aged garlic extract for six weeks had decreased inflammatory markers compared to the start of the study.

NIH summary of weight loss, sports products takes dim view of efficacy

01-Feb-2018 By Hank Schultz

An NIH communique on weight loss and sports performance supplements takes a dim view of the science backing for these ingredients, while at the same time providing a valuable service to industry, sources said.

FDA calls for safety recall, disallows medical food positioning on osteoarthritis product

04-Jan-2018 By Hank Schultz

FDA has branded one of medical food specialist Primus Pharmaceuticals’ products as an unapproved drug and has stipulated a recall based on what it called ‘life threatening’ safety concerns.

Study finds anti-depressant potential in saffron, botanical expert calls results ‘encouraging’

14-Dec-2017 By Adi Menayang

Saffron fared better than a placebo in improving depression symptoms among mothers with mild post-partum depression, say researchers at the Mashhad University of Medical Sciences in Iran.

XSTO Solutions continues US expansion of Cuvitus ingredient with sports nutrition clinical trial

05-Dec-2017 By Adi Menayang

XSTO Solutions, the US distributor of cucumber-derived muscle and joint ingredient Cuvitus, is prepping for further stateside expansion by building the science to support its benefits.

Ayurvedic extract shows joint mobility and comfort improvement in study

03-Nov-2017 By Hank Schultz

A new study on Natreon’s AyuFlex botanical ingredient shows decreased joint pain and increased mobility among a study population of overweight adults. It’s part of the company’s strategy to support entry into new markets with hard data on its ingredients.

Can prebiotics help tackle obesity? New systematic review questions available evidence, draws criticism

05-Sep-2017 By Adi Menayang

In a systematic review, researchers in Brazil concluded that with the science available, “it would not be appropriate to recommend, at the moment”, the clinical use of prebiotics, or its combination with probiotics, to tackle obesity-related health risks.

Burnt out? Rhodiola rosea supplements may help, says new study

18-Aug-2017 By Stephen Daniells

Daily supplements containing Rhodiola rosea extract may improve the symptoms of burnout, suggests data from the first trial to examine the effects of the botanical extract on this modern day condition.

Ritual to focus on proven ingredients as it puts $10.5 million capital raise to work

07-Aug-2017 By Adi Menayang

With millions more in its pockets, multivitamin startup Ritual is keen to upgrade its customer service technology and support clinical trials. However, there is one thing the company will avoid doing, says CEO and founder Katerina Schneider.

Standard Process announces new center in North Carolina focused on innovation

28-Jul-2017 By Hank Schultz

Standard Process has announced a center in North Carolina that will focus on innovation in the use of whole food supplements by health care practitioners.

DayTwo open for business as science expands and investment secured

11-Jul-2017 By Stephen Daniells

Personalized health player DayTwo has announced a new study deepening our understanding of how the microbiome can influence glycemic response.

Clinical data supports safety, bioavailability, and biological activity of pomegranate metabolite

01-May-2017 By Stephen Daniells

Development of products with urolithin A, a metabolite from pomegranate compounds, took a big step forward as scientists reported results from a Phase 1 trial supporting the safety, bioavailability, and biological activity of the compound.

70 product launches in just over 2 years

New clinical data opening doors for Nitrosigine beyond sports nutrition

10-Feb-2017 By Stephen Daniells

Having quickly established its credentials in the sports nutrition space, positive results in recent clinical trials are creating new opportunities for Nutrition 21’s Nitrosigine in the cognitive health sector.

Experts hit back at ‘inaccurate headlines’ after review questions curcumin

02-Feb-2017 By Stephen Daniells

A recent review paper that called into question the potential benefits of curcumin has been misinterpreted to create inaccurate headlines, experts tell NutraIngredients-USA.

Clinical Research: Twenty years of GCP

21-Nov-2016 By Dr Mark Miller, Chief Science Officer & VP, Marketing for Healthy Directions

Good Clinical Practice (GCP) as a quality standard for human studies has been around for 20 years. Its value for supplement consumers and makers is indisputable. However, the nutraceutical industry as well as the regulatory agencies and journals have...

Pomegranate juice may improve knee joint health: Study

11-Jul-2016 By Stephen Daniells

Improvements in physical function and joint stiffness were recorded after six weeks of supplementation with pomegranate juice, report researchers.

Special edition: Bone and joint health

Quality and transparency issues continue to dog shrinking chondroitin category

20-Jun-2016 By Stephen Daniells

Despite support from a prestigious Cochrane Review, many manufacturers to re-emphasize chondroitin and to use efficacious amounts in their supplements, says the President and CEO, Synutra Pure.

Ayurvedic herbs shows joint health support potential: RCT

16-Jun-2016 By Stephen Daniells

Extracts from Terminalia chebula, a plant commonly used in ayurvedic medicine, may improve joint health in people with joint discomfort, says a new study.

PLT assembles dossier of memory claims for Synapsa ingredient

15-Jun-2016 By Hank Schultz

Memory claims are a potential pitfall for marketers of cognitive health products. One ingredient supplier has made navigating those troubled waters easier.

Research partnership, distribution agreement to boost selenium uptake, supplier says

15-Apr-2016 By Hank Schultz

A  clinical trials partnership and a new agreement with AIDP will help boost the market for selenium, says Paul Willis, CEO of Cypress Systems Inc.

For sprinting athletes, sodium phosphate fared (slightly) better than caffeine

14-Apr-2016 By Adi Menayang

Caffeine was observed to not improve repeated-sprint performance, while sodium phosphate was noted to only marginally improve repeated-sprint performance.

HG&H Pharmaceuticals adopts sceletium through ABC’s Adopt-an-Herb Program

23-Feb-2016

HG&H Pharmaceuticals has ‘adopted’ the South African herb sceletium through the ABC Adopt-an-Herb Program.

Soy intake may slash heart disease risk by 12%, but only for equol producers

09-Feb-2016 By Stephen Daniells

Soy supplements may reduce the risk of cardiovascular risk for people able to produce equol, a microbial-derived metabolite of the isoflavone daidzein, but equol supplements themselves may not have the same effects, says a new study.

Round-up: Recent supplement industry advertising challenges by ASRC

08-Feb-2016 By Adi Menayang

In the past few months, five nutritional supplements by various brands have been investigated by two branches of the ASRC. Two of these products have been discontinued

Chr. Hansen targets diabetes with next-generation probiotic deal

20-Jan-2016 By Will Chu

A collaboration between Chr. Hansen and Caelus Health will focus on the development of Eubacterium hallii as a next generation probiotic for prevention and treatment of metabolic disease. 

Using efficacious dosages founding principle for new supplement line

18-Jan-2016 By Hank Schultz

Supplement company Specialty Nutrition Group is partnering with GNC to launch a line of supplements that have clinically relevant dosages as their foundational principle.

Does search for single component active constituents throw baby out with bath water?

11-Dec-2015 By Hank Schultz

Pharmaceutical-style reductionism has been the order of the day in the dietary supplement business. But strong synergistic countercurrents still exist, generated by product developers adhering to older traditions such as TCM and Ayurveda.

Innophos named exclusive distributors of Theracurmin and EMIQ

11-Dec-2015

Theravalues Corporation has named Innophos Nutrition as the exclusive US distributor for its Theracurmin curcumin and EMIQ quercetin ingredients.

'no evidence of benefit in this population'

Study quashes claim probiotic reduces NEC, sepsis & death in preterm infants

26-Nov-2015 By Annie Harrison-Dunn

There is no evidence that the probiotic strain Bifidobacterium breve can reduce the risk of necrotising enterocolitis (NEC), late-onset sepsis and death in preterm infants, a study of 1315 infants has found.  

Bayer vs FTC: Not the battle of the experts many were expecting…

05-Oct-2015 By Stephen Daniells

The Bayer vs FTC case in the US District Court of New Jersey is full of lessons, including what does and does not constitute ‘competent and reliable scientific evidence’, and the importance of having experts who know the space.

UPDATED: NPA calls decision a "win for the industry and consumers"

‘A drug-level randomized controlled clinical trial for a supplement has never been the standard’: Bayer ‘gratified’ with court decision vs FTC

29-Sep-2015 By Stephen Daniells

The hotly anticipated decision in the dispute between Bayer and the US Federal Trade Commission over claims in support of Phillips’ Colon Health is in, with a judge ruling in favor of the company.

Health Canada grants Verisol a Natural Product Number, confirms efficacy and safety

15-Jun-2015 By Stephen DANIELLS

Health Canada’s Natural and Non-prescription Health Product Directorate (NNHPD) has confirmed the clinical efficacy of Gelita’s Verisol collagen peptide for improving skin physiology.

Fenugreek extract may boost woman’s healthy sexual desire: Human RCT

28-May-2015 By Stephen DANIELLS

Daily supplements of an extract from Fenugreek may enhance female libido, say results of a double-blind randomized placebo controlled study.

FTC seeks injunction against weight loss supplement marketer over false claims, fraudulent 'risk free' offer

14-May-2015 By Hank Schultz

The Federal Trade Commission, alleging false advertising, is seeking a permanent injunction to prevent Lunada Biomedical Inc. from claiming that its dietary supplement Amberen causes substantial weight loss.

Catechins, but not quercetin, behind some of cocoa & tea’s benefits

02-Mar-2015 By Stephen DANIELLS

Supplementation with epicatechin may beneficially affect insulin levels and insulin resistance, but another flavonoid quercetin had no effect, says a new study from The Netherlands.

Greenteaspoon CSO: ‘We’re convinced polyphenol prebiotics will play a huge role in advancing our understanding of the importance of the gut mucus layer in health and wellness’

27-Feb-2015 By Stephen Daniells

A proprietary blend of superfruit and green tea may support healthy digestion, says data from a double-blind and placebo-controlled study that supports the prebiotic potential of polyphenols.

Vitamin E linked to lower heart attack risk, but only if used alone?

10-Feb-2015 By Stephen Daniells

Supplements of vitamin E may reduce the risk of myocardial infarction, says a new meta-analysis of 16 randomized clinical trials, but the effects seem to be canceled out when given other antioxidants.

Cochrane review should ‘end all the debates on chondroitin’s efficacy for osteoarthritis’

06-Feb-2015 By Stephen DANIELLS

Chondroitin sulfate is safe and efficacious for improving pain and functional capacity in people with osteoarthritis, says a new review from the prestigious Cochrane Collaboration.

Supplement shows promising results in cognition, mood in large scale study

19-Jan-2015 By Hank Schultz

A recent large scale study published in the Journal of Alzheimer’s Disease confirms earlier results for a nutraceutical formulation branded as Perceptiv in showing improved performance on standardized tests and improved mood for subjects diagnosed with...

PLMI 2014 Thought Leaders Consortium

Strategic product development for a personalized, practitioner-driven approach to cardiovascular, metabolic, and cognitive health

17-Dec-2014 By Barry W. Ritz, PhD, VP Scientific and Regulatory Affairs, Atrium Innovations Inc

Developing innovative dietary supplement products for nutrition-trained or functional medicine practitioners who engage in a personalized approach to patient management presents interesting challenges and opportunities. How do you develop, manufacture...