Multivitamin-ginseng formula relieves stress markers in controlled trial

By Hank Schultz

- Last updated on GMT

©Getty Images - gawrav
©Getty Images - gawrav

Related tags stress management multivitamins Dietary supplements Ginseng Minerals

A supplement formula consisting of vitamins, minerals and ginseng was found to lessen psychological symptoms and blood markers of stress in a controlled trial, the manufacturer claims.

The new research was published in the journal Frontiers in Psychiatry​.  It was the work of experts associated with teh manufacturer of the Indian/American firm Trivedi Global, based in Henderson, NV and Thane, India.  The company funded the study.

The research material was a formula known as TRI 360.  It consists of vitamin A, as beta carotene (833 IU), vitamin B6 (0.75 mg), vitamin B12 (3.5 μg), vitamin C (25 mg), vitamin D3 (400 IU), vitamin E (11 IU), calcium chloride (50 mg), iron sulfate (3.5 mg), magnesium gluconate (20 mg), zinc chloride (5 mg), sodium selenate (12.5 μg), and ginseng powder (100 mg). 

The study, according to the authors, ws structured as a “randomized, active-controlled, open-label, single-center, parallel-group design.”  It was presumably conducted at the company’s research facility in India although that wasn’t specified in the research report, as all of the study participants were listed as  ‘Asian’ in terms of their ethnicity.

Blizzard of psychological factors assessed

Subjects were younger, aged about 25 to 40, and included both males and females.  The subject were generally healthy, and ranged from slender to moderately obese. All of the subjects chosen for the study reported at least one stress-related complaint, such as sleep disturbances, anxiety, depression, fatigue and others. 

In the end, the researchers recruited 42 subjects for each arm of the study.  Each group consisted of 24 men and 18 women.  The groups consumed either one TRI 360 capsule or a placebo both morning and night for 180 days.

The researchers assessed the effects of supplementation on the psychological symptoms via questionnaires.  They reported to have found statistically significant reductions in a host of these factors, though the fact that so many were assessed means only a few individuals would be reporting for each symptom in most cases.

Findings in blood analysis

Perhaps more significant were the results of the blood draws, which were done at baseline, 90 and 180 days. The researchers reported finding reductions in the stress related hormones 17-β-estradiol and oxytocin.

They also assessed the levels of klotho protein, which has been associated with anti aging​.  They claimed levels of this protein were 372% higher at day 90 and more than 500% greater at day 180 in the TRI 360 group compared to placebo.

Neurotransmitter levels were also increased, with the TRI 360 group showing higher levels of both acetylcholine and norepinephrine. 

“Overall, these findings support the daily intake of TRI 360 supplementation as a potentially safe dietary supplement for improving perceived psychological symptoms related to fatigue and stress,”​ the authors concluded.

Source: Frontiers in Psychiatry
Efficacy of a novel proprietary dietary supplement (TRI 360) on psychological symptoms and stress-related quality of life in adult subjects: A randomized controlled clinical trial
Authors: Trivedi MK, et al

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