Astaxanthin boosts post-exercise immunity without anti-inflammatory effect

By Asia Sherman

- Last updated on GMT

© Steve Prezant / Getty Images
© Steve Prezant / Getty Images

Related tags Astaxanthin Haematococcus pluvialis Immunity Anti-inflammatory Sports nutrition

Short-term astaxanthin supplementation provided immune support for runners during rigorous exercise and uniquely countered decreases in plasma immunoglobulin levels, according to a recent study. It did not, however, offset exercise-induced muscle soreness, muscle damage and inflammation.

“The most significant finding is the robust effect of astaxanthin supplementation (8 mg/d, 4-week period) in countering exercise-induced decreases in immune-related proteins, especially immunoglobulins,” said David Nieman, DrPH, FACSM,​ director at the Appalachian State University Human Performance Laboratory at the North Carolina Research Campus ​and a lead author on the study. 

The research, published in the journal Frontiers in Nutrition​, was supported by Israeli nutrient supplier Lycored, which provided the algae astaxanthin used in the study.

Astaxanthin in context

Athletes experience increases in inflammation, oxidative stress and immune dysfunction during intense training and competition, which the study authors hypothesized could be moderated by astaxanthin due to its unique molecular structure and free radical scavenging abilities. 

Found in different types of algae and phytoplankton, astaxanthin is a dark red pigment that gives salmon, shrimp and krill their reddish color. Previous research indicates that supplementation with 8 mg a day of astaxanthin over four weeks significantly increased plasma astaxanthin​ in human subjects and confers potent antioxidant, immunomodulatory and anti-inflammatory effects in various contexts.

In this study, the team of North Carolina-based researchers used a human systems biology approach to improve the ability to capture trial differences using untargeted proteomics and targeted oxylipin and cytokine panels. They noted that the use of untargeted proteomics (the large-scale study of the proteome or the entire set of proteins produced in response to a wide variety of stressors) is an emerging science with a high potential to improve scientific understanding of the complex responses from nutrition interventions within an exercise context.

“Context is everything when interpreting data generated from well-designed clinical trials,” Dr. Nieman told NutraIngredients-USA.  “We used exercise stress to induce inflammation, muscle damage and immune dysfunction. Within that context, astaxanthin supplementation exerted immune-regulatory effects.  In other types of studies (e.g., obesity-induced systemic inflammation), astaxanthin may exert anti-inflammatory effects.”

Study details

The randomized, double-blind, placebo controlled, crossover trial recruited 18 healthy runners between the ages of 18 and 57 years (11 male and 7 female). Participants consumed either 8 mg of algae astaxanthin or a starch placebo daily for four weeks prior to running 2.25 hours at close to 70%VO2max​ (including 30 min of 10% downhill running). 

Blood samples were collected before and after supplementation, immediately post-exercise and at 1.5, 3 and 24 h-post-exercise for analysis. After a two-week washout period, subjects switched groups and repeated all procedures.

“Astaxanthin supplementation had no effect on exercise-induced muscle soreness, muscle damage and increases in six plasma cytokines and 42 oxylipins,” the study reported. “Notably, astaxanthin supplementation countered exercise-induced decreases in 82 plasma proteins (during 24 h recovery).” 

The biological process analysis revealed that most of these proteins were involved in immune-related functions such as defense responses, complement activation and humoral immune system responses. The research team also identified 20 plasma immunoglobulins that differed significantly between the astaxanthin and placebo groups and found that plasma immunoglobulin levels decreased significantly post-exercise but recovered after the 24 h post-exercise recovery period in the astaxanthin but not the placebo trial.

“The strength of our study design was including untargeted proteomics to capture this novel finding,” Dr. Nieman said. “Cell culture studies indicated that astaxanthin augmented immunoglobulin production, and our randomized clinical trial with runners confirmed this immune-regulatory effect.”

Source: Frontiers in Nutrition
“Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins”
doi: doi.org/10.3389/fnut.2023.1143385
Authors: David C. Nieman et al.

Related news

Show more

Related products

show more

Stay one step ahead in the collagen market

Stay one step ahead in the collagen market

Content provided by Bioiberica | 26-Feb-2024 | White Paper

It's no secret that interest in collagen is at an all-time high – especially for joint health. This presents a real opportunity for manufacturers...

Kaneka Ubiquinol® and Preconception Health

Kaneka Ubiquinol® and Preconception Health

Content provided by Kaneka Nutrients – Manufacturer and Supplier of Kaneka Ubiquinol® | 02-Feb-2024 | White Paper

An ally in the fight against oxidative stress, Kaneka Ubiquinol® offers antioxidant support for men and women concerned about reproductive health.

Dynamic Duo - More Power, Less Fatigue

Dynamic Duo - More Power, Less Fatigue

Content provided by Enovate Biolife LLC | 23-Jan-2024 | White Paper

Better physical performance & vitality have deep connections to muscular as well as cardio-respiratory health.

A Healthier Aging Experience with Kaneka Ubiquinol®

A Healthier Aging Experience with Kaneka Ubiquinol®

Content provided by Kaneka Nutrients – Manufacturer and Supplier of Kaneka Ubiquinol® | 01-Dec-2023 | White Paper

As the world’s population ages, our need for healthy aging products grows. Exciting research has shown that Kaneka Ubiquinol® protects against premature...

Related suppliers

Follow us

Products

View more

Webinars