Quicksilver pairs resveratrol, quercetin to achieve NAD+ boost

By Hank Schultz

- Last updated on GMT

©Getty Images - Prostock Studio
©Getty Images - Prostock Studio

Related tags Resveratrol Resveratrol supplementation Polyphenols

Quicksilver Scientific is upping the ante in the anti aging arena with a liposomal supplement that claims to boost NAD+ with a variety of ingredients.

Quicksilver is a Colorado company specializing in liposomal delivery systems. The company manufacturers a variety of products that are sold direct to consumers and through the practitioner channel.

The new offering targets the NAD+ pathway, which is a recent hot area of anti aging product development. 

NAD+ current target of anti aging product development

NAD+ is nicotinamide adenine dinucleotide, a coenzyme that helps other enzymes work at the cellular level. These compounds function in hundreds of different biological and chemical reactions and are needed by cells to stay healthy and keep us alive. NAD+, which is found in all cells in the human body, is fundamentally important for energy generation, DNA repair and cell signaling. NAD+ is viewed as important to supporting physical and mental performance and aiding in cardiometabolic health.

Quicksilver founder and CEO Chris Shade, PhD, said NAD+ naturally declines as people age.  Maintaining adequate levels of this coenzyeme has been seen as vital in forestalling cellular senescence, that period in people’s lives when cells start to fail and the tissues in the body start to degrade. Research shows the levels of NAD+ in humans at age 50 is half of what they had when they were age 20.

SIRTUIN-1 activation bound up with NAD+ boost

It’s a further development, Shade said, of the earlier anti aging story that focused on ways to activate the SIRTUIN-1 gene. This encodes the formation of sirtuin proteins, a high level of  which appears to mimic the effect of ultra low calorie diets.  Severe caloric restriction (40% or more) has been shown in a mouse model to lead to startling increases in longevity, but researching the potential longevity promoting effects of a near starvation level diet in humans has proven to be impractical.

Resveratrol, a polyphenol derived from red wine grapes, Japanese knotweed and other sources, was one of the first ingredients put forward to assist in SIRTUIN-1 activation.

“NAD+ has emerged as the core of the anti aging category. That is involved with SIRTUIN-1 activation, but that is predicated on having adequate levels of NAD+ in the first place,”​ Shade told NutraIngredients-USA​.

The new product, called NAD+ Platinum, combines resveratrol with the antioxidant ingredient quercetin and B vitamins in a liposomal delivery vehicle.  Like many polyphenols, resveratrol and quercetin are poorly absorbed in their base forms.

“By supplementing this crucial coenzyme with our highly bioavailable nutraceutical blend NAD+ Platinum, we help promote a metabolic vigor that naturally declines with age,” ​Shade said.

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