Pterostilbene polyphenol that is often compared to its cousin resveratrol, although it has been found to be much more metabolically stable and bioavailable due to its molecular structure. Pterostilbene can be founding a number of plants.
Herbal extract manufacturer and supplier Sabinsa offers pterostilbene, the active compound in Sabinsa’s Silbinol range of products. It is extracted from the heartwood of Pterocarpus marsupium, also known as the Indian Kino Tree. Pterocarpus is a genus of pantropical trees in the Fabaceae family and originates from dry, hilly areas of India, Sri Lanka and Nepal.
The ingredient was the subject of a new study published by Sabinsa researchers and academic scientists from Taiwan and China in the journal Molecular Nutrition and Food Research.
The joint study suggests cardioprotective properties in pterostilbene after the researchers found that it reduces Trimethylamine-N-oxide (TMAO) formation and decreases vascular inflammation in mice. TMAO is a risk factor for atherosclerosis, heart disease as well as for colorectal cancer in postmenopausal women. With that mind, Sabinsa said, ”Consequently, ingredients that lower TMAO are welcome additions to the repertoire of supplements.”
The researchers found that pterostilbene was shown to influence gut microbiota and lower inflammatory genes in the mice.
The study concluded, “These data suggest that amelioration of carnitine‐induced vascular inflammation after consumption of pterostilbene is partially mediated via modulation of gut microbiota composition and hepatic enzyme FMO3 gene expression.”
In other words, “While we’ve known that Silbinol’s pterostilbene is a powerful antioxidant, this research has significantly advanced our understanding of its mechanisms of action and benefits for heart health,” said Dr. Muhammed Majeed, Sabinsa’s founder.
When asked about studies beyond mice, Majeed told NutraIngredients-USA that Sabinsa doesn't have any human studies in the pipeline, "but it's an intriguing area of research."
Molecular Nutrition and Food Research
Volume 63, Issue 20 Oct 2019 1900514 doi.org/10.1002/mnfr.201900514
“Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine‐N‐Oxide Reduction and Mechanism of Microbiota Regulation”
Author: Y. Koh, et al.