The fruit of Forsythia suspensa is widely distributed in Eastern Asia and has been used in many traditional medicine cultures from the region to alleviate inflammation and treat gastrointestinal issues.
Its benefits for bone health, however, were still limited. The researchers observed the effects of feeding a water extract of F. suspensa to mice that have gone through an ovariectomy, which induces bone loss similar to postmenopausal human females.
“We showed that [the extract] inhibited osteoclast differentiation and suppressed estrogen deficiency-induced bone loss and lipid accumulation in bone marrow,” they reported in their paper, published last week in the journal Nutrients.
The mechanism of action remains unclear and requires further studies, but they argued that the phytochemical composition of the plant influences the expression and activation of signaling molecules.
The researchers observed mice in four different groups, each with five mice. The first group was a control group consisting of normal female mice, while the remaining three groups all had ovariectomized mice to induce bone loss.
Among the ovariectomized mice, one group received a low dose of the plant extract, another with a high dose, and the final group received no extract.
Extracts were fed through oral gavage once daily for four weeks.
To measure bone loss, the researchers performed histological analyses on femurs. They also analyzed the mice’s bone marrows.
They observed a compaction and thickening of the cancellous bone in plant extract supplemented mice compared to the mice not receiving the extract, indicating that the extract may alleviate ovariectomy—induced bone loss independently of estrogenic effects.
“Natural products and herbal medicines are gaining interest for their potential to improve bone health in osteoporosis patients and healthy individuals,” they argued.
“These findings provide evidence that Forsythia suspensa is an effective naturally derived alternative to standard therapies for the treatment of postmenopausal osteoporosis.”
Published online, https://doi.org/10.3390/nu11081831
“Forsythia suspensa Protects against Bone Loss in Ovariectomized Mice”
Authors: Youn-Hwan Hwang, et al.