Omega-3s & omega-6s show promise against ADHD: Cochrane review


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Related tags Attention-deficit hyperactivity disorder

Omega-3s & omega-6s show promise against ADHD
A combination of omega-3 and omega-6 fatty acids may help with attention deficit hyperactivity disorder (ADHD), says a new review from the prestigious Cochrane Collaboration.

Australian scientists report that, while there is limited data to support a potential improvement in ADHD with combined omega-3 and omega-6 supplementation, the evidence is currently too limited to allow for any recommendations.

“More high-quality research is needed in this area in order to identify more conclusively the effectiveness or otherwise of [polyunsaturated fatty acids (PUFA)] supplementation in children and adolescents with ADHD,”​ wrote researchers led by Donna Gillies from the Western Sydney and Nepean Blue Mountains Mental Health Service in Australia.

“Future studies should use active PUFA supplements at dosages shown to significantly increase circulating PUFA and, in particular, the ratio of omega-3 to omega-6 PUFA, and use supplements for considerably longer periods than the maximum of 16 weeks identified in this review.”


Led by Commenting on the review’s conclusions, Harry Rice, PhD, VP of scientific and regulatory affairs for GOED, the omega-3 trade association, told NutraIngredients-USA: “While the review was not specific to the long-chain omega-3s, EPA and DHA, based upon my assessment of the scientific literature specific to the long-chain omega-3s and attention deficit disorder (ADD) with or without hyperactivity, there is promising, yet insufficient (at least for the time being), evidence to conclude that the long-chain omega-3s  are beneficial for treating the symptoms of ADD.

“There is great heterogeneity in terms of study design, including subject characteristics, dose of omega-3s administered and study duration. As is often times the case, further research is needed (and in fact is ongoing).

“Hopefully, future research will take into account the long-chain omega-3s status of the subjects.”

Review details

Gillies and her co-workers analyzed data from 13 trials for 1,011 children and adolescents. There was a lot of variation between the studies, with five comparing omega-3 to placebo, two comparing combined omega-3/omega-6 supplements to placebo, one comparing omega-3 to another supplement, two comparing omega-6 to placebo, one compared omega-3 to omega-6, and one compared omega-6 PUFA to dexamphetamine.

“There was a significantly higher likelihood of improvement in the group receiving omega-3/6 PUFA compared to placebo,”​ report the researchers, with a 119% increase in likelihood of improvement.

However, there were no improvements overall for PUFA supplements and ADHD, nor were there any overall benefits for inattention scores, hyperactivity, or behavior.

“At this stage, there is insufficient evidence to conclude that PUFA supplementation is of benefit in children and adolescents with ADHD.

“As there were no identified harms associated with PUFA supplementation, there is also insufficient evidence to conclude that it is harmful to children and adolescents with ADHD.”

Source: Cochrane Database Systematic Reviews
2012 Jul 11;7:CD007986.
“Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents”
Authors: D. Gillies, J.Kh. Sinn, S.S. Lad, M.J. Leach, M.J. Ross

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Further research will prove omega-3's are key factor in human health

Posted by Omegafort SCC,

We are confident that further research will add to the growing body of solid evidence that omega-3's are a key factor in benefiting human health in terms of a number of conditions, including ADHD. We have amassed a wealth of scientific research on the effects of omega-3's on ADHD and other conditions on our web site,

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Not quite what I was hoping for...

Posted by Donna Acosta,

I agree with previous commenters...the article isn't exactly the good news I was hoping for. Hopefully further research will be more forthcoming!

Jean, I agree with you in particular. I have severe ADD and have never gone the medication route (aside from using caffeine in the AMs and afternoons). I've used cognitive, behavioral, and environmental methods instead, with excellent success. People are *surprised* to learn I have ADD, and I can't say enough about how happy I am to finally be able to set and accomplish goals, even long-term goals. Best wishes, and keep up the good work! :)

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An alternative for ADHD treatment

Posted by Jean Nystrom,

I have done a lot of homework on this topic. I found no quantitative statistics that convinced me that medication is the way to go. I feel that parents with children and persons suffering from ADHD/ADD should seek alternatives to the current medications available. I have a child with ADHD. I tried the Ritalin with little to no success. I found the drug made my child lethargic and once it wore off she would either crash or become even more hyper-active. Believe me, I tried it for a period of time to see if it would build up in her system and alleviate not only the behavior but the side effects. It did not. After doing much research I found a program that is working for my child and my family. I use Play Attention. Play Attention is a program that builds behavioral shaping. Since investing my child's mental health into this platform I have now learned that they are using this program at nuclear power plants, nascar mechanics use it, why? To focus and reach their maximum potential. Personally, I just want my child to live a normal, loving life and enjoy life to the maximum. Jnystrom

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