Vitamin E may boost immune function: Mouse study

By Stephen Daniells

- Last updated on GMT

Related tags: Immune system, Tocotrienol, Tocopherol

Dietary supplements of vitamin E tocotrienols may enhance immune function and help us maintain our immune health as we age, suggests a new study.

Scientists from Tufts University report that mice fed dietary supplements of alpha-tocotrienols experienced improvements in the function of T cell function. The findings are published in the Journal of Nutrition​.

If the results can be repeated in future studies it may see tocotrienols added to the burgeoning immune health market. In 2008, nine per cent of nutraceutical claims were reportedly for immune health. The area is growing, but science is key to supporting the claims.

The new study investigated the effects of tocotrienols on immune function in old and young mice. The animals were fed 0.1 per cent Tocomin 50 per cent (Carotech), which is a mixture of tocotrienols and alpha-tocopherols, or a control diet containing only tocopherol, for six weeks.

At the beginning of the study the researchers noted that the immune function of the older mice was reduced, compared with the younger mice, as evidenced by the lower levels of the cytokines, interleukin-4 (IL-4), IL-6, and IL-10.

Older mice fed the tocotrienol supplement displayed a greater level of lymphocyte proliferation, a marker of how quickly white blood cells can reproduce in response to infection, than old mice fed the control.

Furthermore, mice of both ages fed the tocotrienol supplement had higher levels of the interleukin-1beta, a cytokine released by immune cells (macrophages).

“These results suggest a beneficial effect of tocotrienols in improving the age-related decline in T cell function,” ​wrote the researchers.

The vitamin E

There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is the most common form in the American diet.

Tocotrienols are only minor components in plants, although several sources with relatively high levels include palm oil, cereal grains and rice bran.

While the majority of research on vitamin E has focused on alpha-Toc, studies into tocotrienols account for less than one per cent of all research into vitamin E.

Source: Journal of Nutrition
Published online ahead of print, doi: 10.3945/jn.110.121434
“Dietary Supplementation with Tocotrienols Enhances Immune Function in C57BL/6 Mice”
Authors: Z. Ren, M. Pae, M.C. Dao, D. Smith, S.N. Meydani, D. Wu

Related news

Show more

Related products

show more

Setria® is leading the way!

Setria® is leading the way!

Kyowa Hakko USA | 09-Nov-2018 | Technical / White Paper

The data is in! Setria® Glutathione is the No. 1 selling brand of glutathione in natural product supermarkets, according to SPINS, an industry source of...

Human Bifidobacteria, selected by Mother’s milk

Human Bifidobacteria, selected by Mother’s milk

Morinaga Milk Industry Co., Ltd. | 01-Nov-2018 | Technical / White Paper

Health promoting traits of Bifidobacteria are well-known around the world and its effect is strain-specific, however, whether the residential origin of...

K2 for Heart Health? MenaQ7 Only Proven, Patented

K2 for Heart Health? MenaQ7 Only Proven, Patented

NattoPharma USA, Inc. | 22-Oct-2018 | Research Study

Vitamin K2 has earned media and the medical community’s attention due to a strong body of evidence showing it simultaneously supports bone and cardiovascular...

Related suppliers

Follow us

Featured Events

View more


View more