Agave fibers show gut health and weight management potential

By Stephen Daniells

- Last updated on GMT

© Getty Images / arturogi
© Getty Images / arturogi

Related tags Gut microbiota Gut flora Mexico

Extracts from agave may boost the diversity of the gut microbiota and help promote weight management, says a new study using lab mice. 

Supplementing a high-fat diet with agavins, branched neo-fructans derived from Agave tequilana​, led to a “normalization” in the ratio of Firmicutes​ to Bacteroidetes​, according to scientists from Center for research and advanced studies of the IPN (Mexico) and Sejong University in Seoul (Korea).

The Firmicutes/Bacteroidetes​ ratio is reportedly a good biomarker for obesity, with data from a 2005 study indicating that obese mice had lower levels of Bacteroidetes​ and higher levels of Firmicutes​, compared with lean mice.

Data published in the journal Nutrients​ also indicated that agavin supplementation was associated with weight loss and an increase in the production of short chain fatty acids (SCFA) at the start of the large intestine (cecum).

“These results could provide novel insight to develop a new supplementary strategy using agavins to modulate gut microbiota in overweight or obese individuals, which might have positive consequences on body weight loss,” ​wrote the researchers.

Prebiotic effects

The potential gut benefits of consuming agave fructans has been reported previously, and prebiotic ingredients based on agave are commercially available from several companies, such as Mexico’s Bustar Alimentos​ and US-based The Tierra Group​.

A 2010 study​ by scientists from the National Autonomous University of Mexico and the University of Reading (UK) reported that inulin extracted from Agave tequilana​ boosted the numbers of bifidobacteria​ and lactobacilli​ to a similar extent to other commercial inulins (Journal of Applied Microbiology,​ Vol. 108, pp. 2114-2121).

The new study is reportedly the first to show the global effects of a diet shift and supplementation with agavins on the microbiota composition in the cecum in overweight mice.

Study details


An expert panel convened by the International Scientific Association for Probiotics and Prebiotics (ISAPP) recently updated​ the definition of ‘prebiotics’ to be: “A substrate that is selectively utilized by host microorganisms conferring a health benefit”.

The researchers divided lab mice into two groups for five weeks: one group consumed a standard lab mouse diet while the other consumed a high-fat diet. Overweight mice from the high-fat group were then divided into three groups: The first group was shifted back to the standard diet, while the other groups were kept on high fat diets and supplemented with either agavins or oligofructose for another five weeks.

Results showed that mice the high fat diet for the first five weeks displayed a significant decrease in the diversity of the microbiota in the cecum, with an increased Firmicutes/Bacteroidetes​ ratio and lower SCFA levels.

Shifting these animals back onto the standard diet reversed these changes, with diversity and SCFA levels increasing.

Animals kept on the high-fat diet and supplemented with agavins or oligofructose showed a partial restoration in the microbiota, said the researchers. The Firmicutes/Bacteroides​ ratio was normalized, while SCFA levels also increased, they added.


Supplementation with agavins led to increases in Klebsiella​ and Citrobacter​, which are members of the Enterobacteriaceae​ family. ​Enterobacteriaceae have also been reported to increase during weight loss in obese mice and humans,” ​wrote the reseachers.

“[T]he enrichment of members of ​Enterobacteriaceae has not been reported previously under a prebiotic supplement, which opens opportunities to explore new probiotics,” ​they concluded.

Source: Nutrients
2017, 9​(9), 821; doi:10.3390/nu9090821
“Modulation of Gut Microbiota of Overweight Mice by Agavins and Their Association with Body Weight Loss”
Authors: A. Huazano-Garcia et al.

Related news

Related products

show more

Explore New Opportunities in Postbiotics

Explore New Opportunities in Postbiotics

Content provided by CJ BIO | 21-Jun-2024 | White Paper

Explore the latest trends and versatile postbiotics to propel your brand forward. As a biotics market expert, staying ahead with innovation is crucial.

Related suppliers

Follow us


View more