In the highly regulated world of dietary supplements, a clear distinction exists between the responsibilities and considerations of the Own Label Distributor (OLD) and those of the Contract Development and Manufacturing Organization (CDMO), particularly concerning engineering and manufacturing specifications. While the OLD defines the “what” of the product, the CDMO is responsible for the “how”, employing robust engineering and quality control to ensure products meet specifications and regulatory requirements. Today a clear working partnership between the two is more critical than ever before.