Technical / White Paper
In vitro–in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli
Findings of a recent study conducted by researchers of APC Microbiome Ireland showed significant benefit of utilizing a scientifically validated in vitro gut model (M-SHIME) prior to a human clinical trial. The in vitro analysis conducted by Duysburgh et al. (2020), reported a significant increase of Bifidobacterium and Lactobacillus levels in response to prebiotic oat treatment, confirming the validity of a human clinical trial. This resulted in a partnership with Atlantia Clinical Trials to further test the validity of prebiotics to stimulate Lactobacillaceae and Bifidobacteriaceae/ increasing propionate and butyrate production.