Collagen peptides boost bone health effects of calcium + vitamin D: RCT

By Stephen Daniells

- Last updated on GMT

© VadimZakirov / Getty Images
© VadimZakirov / Getty Images

Related tags Collagen Collagen peptides Bone health Calcium Vitamin d

Adding collagen peptides to a regimen of calcium and vitamin D improved measures of bone health compared to calcium +D alone, says a new study from Greece with postmenopausal women with osteopenia.

The study found that 12 months of supplementation led to significant improvements in trabecular and cortical bone properties at the shin bone (tibia).

Researchers from the National and Kapodistrian University of Athens and the KAT General Hospital of Athens also found that the three-component supplement decreased bone turnover in the women.

“In this randomized 1-yr prospective study, supplementation with calcium, vitamin D with [collagen peptides] resulted in a significant increase of trabecular [bone mineral content], [bone cross-sectional area] and [volumetric bone mineral density] at the tibia, as compared with supplementation without [collagen peptides],”​ they wrote in the Journal of Clinical Densitometry.

“At the cortical site, the percent changes in cortical [volumetric bone mineral density] were greater, and the mean 12-mo values of cort [bone mineral content] and [volumetric bone mineral density] increased following [collagen peptides] supplementation.”

Study details

While the new study is reportedly the first to explore the effects of the collagen peptides in combination with calcium and vitamin D on bone mineral density (BMD) and bone geometry, three other studies have examined the potential combination of collagen with calcium and vitamin D. Those studies also found that measures of bone health were improved by adding collagen peptides to calcium and D.

Fifty-one postmenopausal women with osteopenia were recruited to participate in the study and were randomly assigned to receive 500 mg calcium and 400 IU vitamin D3 per day with or without 5 grams per day of collagen peptides (Fortibone, Gelita). The three-component formulation is commercially available in Greece under the Colabone brand from VivaPharm SA, and VivaPharm supported the study.

Results showed that, compared to calcium and vitamin D only, total bone mineral content (BMC) of women in the Colabone group was 1.96% higher, while trabecular BMC was 5.24% higher and volumetric bone mineral density (vBMD) was 2.54% higher.

At the cortical site, the Colabone group had total and cortical vBMD increases of 1.01% and 0.67%, respectively.

The collagen peptides plus calcium and vitamin D group also had a higher mean areal bone mineral density (aBMD) at the spine, compared to the calcium plus D group only.

“The present study shows that the addition of CPs to calcium and vitamin D supplementation for 12 mo in postmenopausal women improves trabecular and cortical bone properties at the tibia and may positively affect aBMD at the lumbar spine,” ​wrote the researchers.

“Nevertheless, the elucidation of the physiology and the effects of the use of calcium, vitamin D with CPs supplementation for more than a year in postmenopausal women with osteopenia for the prevention of osteoporosis should be addressed in future studies.”

Source: Journal of Clinical Densitometry
Published online ahead of print, doi: 10.1016/j.jocd.2021.11.011
“Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia”
Authors: K. Lampropoulou-Adamidou et al.

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