Kyowa Hakko launches new NO booster for exercise performance

By Stephen Daniells contact

- Last updated on GMT

© Getty Images / mihtiander
© Getty Images / mihtiander

Related tags: exercise performance, Sports nutrition, L-citrulline, L-arginine

Kyowa Hakko USA has launched a new ingredient for exercise performance brands that combines its l-citrulline and l-arginine to boost nitric oxide production and levels more rapidly than l-arginine alone.

The benefits of the ingredient, which is branded Velox, are supported by two published papers: The first was published in 2017 in Bioscience, Biotechnology, and Biochemistry*​ and showed that l-citrulline combined with l-arginine increased plasma l-arginine levels in humans more than l-arginine alone.

A second study, published last year in the European Journal of Applied Physiology**​, showed that seven days of supplementation with the combination led to significantly higher NO levels than placebo, and improved exercise performance in male collegiate soccer players.

The second study used daily doses of 1.2 grams per day of each its l-citrulline and l-arginine.


The combination is also covered by four U.S. patents, said Kyowa Hakko: U.S. Patent 8,609,735, U.S. Patent 9,060,980, U.S. Patent 9,622,998, and U.S. Patent 10,052,298. The last patent was granted in August 2018 and covers the use of ingredients and related compounds within the blend. To support claims, a 1:1 ratio is required with effective doses of at least 1.2 grams of Kyowa’s L-Citrulline and 1.2 grams of Kyowa’s L-Arginine, said the company.

BSN Endo Rush
BSN’s EndoRush pre-workout product is formulated with Velox

“With four U.S. patents and clinical studies to support it, introducing this new performance blend to the market from Kyowa Hakko strengthens our position as a company that is committed to ensuring our customers always receive efficacious, ultra-pure, high-quality ingredients, guaranteed,” ​said Elyse Lovett, senior marketing manager of Kyowa Hakko U.S.A. Inc.

Lovett told us that the company sees Velox primarily as a sports nutrition ingredient for exercise performance because the patents and claims are based on that specific group of subjects. 

BSN’s EndoRush​ pre-workout product already contains the ingredient in the US marketplace, while products are also available in Japan​.  

The new ingredient is made in the USA, is non-GMO, and vegetarian, said Kyowa. Citrulline is self-affirmed GRAS, Arginine is an FDA approved food additive. The Velox Performance Blend can be used in a wide variety of food, beverage, and dietary supplement applications, added the company.


* Suzuki T. et al. Biosci Biotechnol Biochem​. 2017, Vol. 81, Number 2, Pages 372-375

** Suzuki I. et al. Eur J Appl Physiol​. 2019; Volume 119, Number 5, Pages 1075–1084

Related news

Related products

show more

Sports nutrition sprints into the mainstream

Sports nutrition sprints into the mainstream

Cargill | 20-Sep-2021 | Infographic

Today's users of sports nutrition products are more likely to be interested in supporting an active lifestyle than building a chiseled physique. Learn...

Protein blends for beverages with wider appeal

Protein blends for beverages with wider appeal

Nellson | 09-Sep-2021 | Case Study

Consumers want it all: protein beverages with plant-based ingredients that have the same appealing taste, texture and appearance of 100% dairy-based drinks....

KetoSure MCT – The Ketogenic Diet & Your Consumer

KetoSure MCT – The Ketogenic Diet & Your Consumer

Glanbia Nutritionals | 11-Aug-2021 | Sponsored Link

The number of new keto-focused food and beverage product launches has doubled in the past year, indicating that there is continued interest among consumers...

Related suppliers

Follow us


View more