Topical microbiome transplant could be key to alleviating eczema, say researchers

By Mary Ellen Shoup contact

- Last updated on GMT


Related tags: Eczema, Atopic dermatitis, microbiome, Probiotic, Probiotic, Bacteria

An effective way of treating atopic dermatitis, commonly known as eczema, could be to apply specific bacteria to the affected areas of the skin, a human clinical trial showed.

Atopic dermatitis (AD) can be characterized by an impaired skin barrier function, susceptibility to Staphylococcus aureus​ skin infections, immune dysregulation, and cutaneous dysbiosis (impaired microbiota).

“Current understanding of the microbiome’s influence on human health has expanded far beyond the original hygiene hypothesis,”​ researchers stated in the study.

A previous clinical trial investigated the potential role that Gram-negative skin bacteria played in eczema and revealed that isolates of one particular bacterium, Roseomonas mucosa (R. mucosa),​ collected from healthy volunteers improved eczema outcomes in mice by improving its skin barrier and improving eczema-like rashes.

More specifically, researchers discovered that R. mucosa​ directly killed Staphylococcus aureus​, a common eczema and skin irritation causing bacteria.

“These preclinical results suggested that interventions targeting the microbiome could provide therapeutic benefit for patients with [eczema],”​ wrote the researchers.

To investigate this hypothesis, 10 adult and five pediatric patients were enrolled in an open-label phase I/II safety and activity trial

Topical good bacteria solution

The adult and guardians of pediatric participants sprayed a solution containing the beneficial bacteria (R. mucosa​) to the inner elbows twice per week for a total of six weeks.

For each dose, patients or parental guardians of the pediatric patients were instructed to empty the contents of an eyedropper into a sprayer vial, wait two to five minutes for reconstitution, and then spray the affected area. All patients reported compliance with all 12 doses.

Patients returned for clinical assessment after completion of the full six weeks of therapy and were contacted remotely 30 days after treatment. 

Need for larger clinical trial

According to researchers, R. mucosa​ was associated with clinical improvement in adults and children with eczema.

The six-week treatment was associated with significant reduction in objective intensity of eczema and reduced subjective regional severe itching of the skin. However, these positive results were found to be true for the inner elbow region only as treatment on the hands did not yield any improvement in eczema symptoms.

“Failure of R. mucosa to impact hand disease may indicate that higher treatment doses would be needed, a different species or strain of bacteria would be required, or that hand disease is not amenable to microbiome treatment,” ​researchers wrote.

“However, given the increased contact with topical antimicrobials on the hands, this finding may also be a consequence of environmental exposures promoting dysbiosis.”

Based on the study’s results, researchers plan to launch a bigger trial with hundreds of patients to further prove these findings.


Want to learn about the latest advances in research into the human microbiome? Join us in Miami next month (June 5-7) for Probiota Americas. 

Learn more about the event here​, including a full list of speakers and how to register.   

Source: ​​JCI insight​.
First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis
Authors: Ian A. Myles, et al.

Related news

Show more

Related products

show more

Natural solution for Healthy Weight management

Natural solution for Healthy Weight management

BIONAP Srl | 23-Nov-2020 | Product Presentation

MOROSIL™ is a standardized solid extract obtained only from the juice of a unique cultivar of Moro red oranges (Citrus sinensis (L.) Osbeck). Moro is the...

It’s time for HRB – A lifelong health partner

It’s time for HRB – A lifelong health partner

Morinaga Milk Industry Co., Ltd. | 19-Nov-2020 | Technical / White Paper

Consumer awareness of the importance of choosing the right probiotics that possess extensive clinical efficacy to address fundamental health problems (e.g.,...

FenuSMART® - Nature’s choice for women health

FenuSMART® - Nature’s choice for women health

Akay Natural Ingredients Private Limited | 29-Oct-2020 | Research Study

Recent clinical studies demonstrated the potential effects of a patented full-spectrum extract of fenugreek (FenuSMART®) in establishing the hormonal balance...

Next-wave sports nutrition innovation today

Next-wave sports nutrition innovation today

ADM | 28-Oct-2020 | Technical / White Paper

Today’s consumers are passionate about embracing health in many aspects of their lives, starting with customizing their nutrition. Rooted in proprietary...

Related suppliers

Follow us


View more