Research supports immune benefits of Ganeden’s new Staimune ingredient
Ganeden launched the new Staimune ingredient earlier this summer, and said it would help to take the clinically documented immune health benefits of its BC30 strain (Bacillus coagulans GBI-30, 6086) into new areas of application where a live probiotic would be inappropriate.
Speaking with NutraIngredients when the ingredient was launched, Dr David Keller, VP of scientific operations at Ganeden, described Staimune as “a new functional ingredient for companies who are looking to add a functional or value-added proposition to a product where they can’t use a probiotic.”
“While BC30 is super stable, and you can put it into more products than most probiotics, there are certain products that you just cannot add any probiotic to.” Dr Keller added that shelf stable beverages and bakery were a driver in the development of the new ingredient.
New data published in the Journal of Inflammation Research supports the immune health benefits of the ingredient, with the data showing that the immune effects of GanedenBC30 cells were maintained, even when inactivated through a commercial production process.
“This study, which is Ganeden’s 27th to be published, validates what the science team had previously discovered—that Staimune does an exceptional job supporting immune health regardless of the inactivation process,” said Dr Keller.
For the new study, Ganeden worked with Oregon-based NIS Labs to investigate the immune activating and anti-inflammatory effects of Staimune on human immune cells in vitro.
White blood cells were isolated from healthy human blood donors were incubated with Staimune for 24 hours and then exposed to a range of pro- and anti-inflammatory cytokines, chemokines, and growth factors.
The results showed that the inactivated bacterial cells responded similarly to the live BC30 cells with respect to immune activation and anti-inflammatory effects.
The researchers also found that Staimune was associated with a selective upregulation of a growth factor called G-CSF, which supports stem cells and is important for tissue repair after trauma and injury.
“The complex properties of inactivated GBI-30 suggest possible multifaceted clinical responses after consumption, involving immune activation, anti-inflammatory effects, and effects involving stem cell mobilization, homing, and reprogramming involved in accelerated repair,” wrote the researchers.
“The direct effects of inactivated GBI-30 are expected to translate to immune activation at the level of the gut mucosa and trigger rapid systemic effects. This is different from a study on the live BC30 where ingested spores will give rise to living bacteria that can colonize the intestinal tract, and where an important part of the biological effects is due to secreted bacterial metabolites,” they concluded.
The company stated that it has also recently completed a human trial, with initial findings demonstrating that Staimune supports a heathy immune system response to different stressors. Details of the trial will be released at a later date.
Source: Journal of Inflammation Research
Volume 2017:10, Pages 107-117, doi: 10.2147/JIR.S141660
“Inactivated probiotic Bacillus coagulans GBI-30 induces complex immune activating, anti-inflammatory, and regenerative markers in vitro”
Authors: G.S. Jensen et al.