TeaCrine poised to rev up market size post self-affirmed GRAS

By Adi Menayang

- Last updated on GMT

Photo: iStock
Photo: iStock

Related tags Gras status Self-affirmed gras status Caffeine

Compound Solutions, the company behind nature identical theacrine called TeaCrine, is aiming to make cognitive plus energy products more mainstream.

“The market has been dominated by ‘energy’ for nearly 15 years. Think Red Bull and Monster,”​ Compound Solutions CEO Matt Titlow told NutraIngredients-USA. “But the next 15 years will be dominated by ‘energy and focus.’ TeaCrine plays a major role in both energy and focus, so it will have a major impact on the energy drink category and the new attention placed on focus.”

It announced its self-affirmed GRAS status last week for its nature identical version of theacrine​, an alkaloid structurally similar to caffeine which is found in some tea leaf varieties. The announcement comes after years of independent assessments. In a press release​, the company confirmed 68 new products featuring TeaCrine​ will be added to distribution so far in 2016, bringing the total product count to 124.

Back in 2014, Titlow shared multiple studies​, both animal and human, that the company was working on to reach self-affirmed GRAS status. The most recent, and what the company called “pivotal” study for the ingredient was accepted for publication last month, a pre-clinical 90-day safety study, due to be published in the Journal of Toxicology.

A comment on the new NDI draft guidance

According to Titlow, the studies conducted on the ingredient so far have accumulated into “a higher standard of safety and reasonable certainty of no harm than is even required for NDI.”

He argued that the burden of safety is equal to a no objection letter from the FDA for GRAS status. “After more than a year of research and hundreds of thousands of dollars, we clinically proved that our TeaCrine is even safer than caffeine on a one-time or daily-use basis. Our approved daily limit includes a 100x safety factor, which means TeaCrine will not cause harm at 100x the approved limit,” ​he said.

Examples include one comparing TeaCrine with caffeine or placebo for energy and mood​ published in Nutrients, ​one that suggests its safety and efficacy to reduce cholesterol​ published in the Journal of the International Society of Sports Nutrition​, and another one vetting the dose required for positive energy, focus, and mood​, published in the Journal of Dietary Supplements.

So even though the specific languages “self-affirmed” GRAS was left off the most recent NDI draft guidance​, Titlow said that the company still has “the confidence to proceed judiciously despite the modified language.”

The future of TeaCrine with its new self-affirmed status

Titlow said that the GRAS status “dramatically increases the potential market size and potential for TeaCrine,”​ as all major food and beverage companies require GRAS-affirmation.

“We are about two months away from completing a fifth clinical study, and we plan to continue researching TeaCrine well beyond that point,”​ he added. “When our pharmacokinetic data is published before year-end, it will add to the inevitability of TeaCrine making it into the cognitive energy and clean energy markets on a mass scale.”

Sports Nutrition forum

Want to hear directly from sports nutrition experts on the category’s latest market and science trends? An panel of experts from Douglas Labs, Mintel, Bodybuilding.com, and the International Society of Sports Nutrition will share their insight at NutraIngredients-USA’s free online Sports Nutrition Forum on Sept. 13. To register click HERE


Related news

Related products

show more

Harness the power of algae for omega-3 innovation

Harness the power of algae for omega-3 innovation

Content provided by dsm-firmenich | 22-May-2024 | Insight Guide

Algal-sourced omega-3s have limitless potential, able to scale to meet the needs of our planet’s population with twice the potency – naturally – and all...

Effera™ Human Equivalent Lactoferrin

Effera™ Human Equivalent Lactoferrin

Content provided by Helaina Inc | 17-May-2024 | Product Brochure

Helaina’s bioactive protein Effera™ is a novel branded ingredient and the first clinically studied Human Lactoferrin on the market. Human Lactoferrin is...

Related suppliers

1 comment


Posted by Melvin Ortiz,

Melvin Ortiz
432 Deland Dr.
Utica, NY. 13502
www.facebook.com/ melvinphysique
Instagram @Melvinphysique

To whom it may concern,

Im writing to you in hopes of taking the responsibility of being sponsored by your company. Im currently a bodybuilder competitor in the Male Physique Class. My humble but also charismatic, outgoing and confident personality make me stand out where ever I go.
I started competing in April this year at the OCB Liberty State Natural in Syracuse, NY where I won all of my classes and came 2nd in the Open Overall. My next show was the INBF Natural USA in Rochester, NY where I came 2nd in my class. Immediately following that I competed in Massachusetts at the Spirit of America and won my WNBF Pro Card. I have also competed at the Mr. America placing second in my class and at 2016 WNBF PRO Universe placing 2nd open overall.
Within six months of competing, I have received pro status in the following organizations, WNBF, NGA, OCB and INBF.
I am registered to compete in November 12 in the NGA Universe 2016 in Coral Springs, FL and planning to compete at the WNBF World Championship in Los Angeles 1 week later. My main goal is to become an IFBB Pro where I can represent my roots, my culture, my country, my beautiful Puerto Rico.
I can say that I am a highly motivated and motivating athlete. People often contact me saying I inspire them and motivate them. I always return the message with gratitude and advice. My following on social media like Facebook and Instagram has grown quickly. I can proudly say that in every place I stand people know Melvin Ortiz and if they don’t I make sure they do.
I will be happy and proud to represent your company at events and social media as you believe is accountable. I understand that in taking on the responsibility of the title of sponsored athlete of your company, I will be expected at all times when in public, and especially on social media, to hold myself accountable for how I represent not only myself, but your company.
I thank you for taking your time to read my sponsorship request, I am grateful for any opportunity you may have in the future to work with your company in a promotional component. I give you my word that no one will work harder than me to promote your product and services.

Kind Regards,

Melvin Ortiz
Male Physique

Report abuse

Follow us


View more