The 6-week study found the effect was caused by the blend of Coleus forskohlii, Salacia reticulata, and Sesamum indicum inhibiting pancreatic lipase, an enzyme that works on fats in the digestive system.
Led by Dr Vladimir Badmaev from American Medical Holdings and featuring researchers from Japanese, Chinese and Taiwanese institutions, the blend was administered at 1000 mg per day to male and female adult subjects with a body mass index (BMI) between 25 and 30.
Those receiving the blend (in four 250 mg soft gels per day) showed higher lipase inhibition, more so with the three extracts together than apart, compared to placebo.
“The in vitro addition of S. indicumto the formula was found to synergistically assist inhibition of the pancreatic lipase in a lower dose range, while moderating the pancreatic lipase inhibition in a higher dose range,” the researchers wrote.
“This dual mechanism of S. indicumwas postulated as a safety mechanism preventing any potential side effects resulting from excessive inhibition of pancreatic lipase activity.”
Dr Badmaev will present some of the findings at Vitafoods Europe next week.
Journal of Functional Foods
15 ( 2 0 1 5 ) 44–51 March 2015
‘Preclinical and clinical effects of Coleus forskohlii, Salacia reticulataand Sesamum indicum modifying pancreatic lipase inhibition in vitro and reducing total body fat’
Authors:Vladimir Badmaev, Yoshitaka Hatakeyama, Noriyuki Yamazaki, Akira Noro, Faizal Mohamed, Chi-Tang Ho, Min-Hsiung Pan