Science short

Resveratrol’s inflammatory potential boosts bone health in obese men: Study

By Shane STARLING contact

- Last updated on GMT

Resveratrol study demonstrates bone benefits
Resveratrol study demonstrates bone benefits

Related tags: Resveratrol, Bone

Resveratrol boosts bone health by stimulating mineralisation and bone formation, a study among 74 middle-aged, obese men has found.

The gold standard double blind, randomised, placebo-controlled research was conducted in Denmark at Aarhus University Hospital gave the men with an average age of 49 and body mass index (BMI) of 33.7 either 1000mg, 150g or placebo daily via supplements.

The primary endpoint was change in bone alkaline phosphatase(BAP) and this measure improved significantly over 16-week study compared to placebo.

“The increase in bone formation and/or mineralisation could explain the temporary decrease in serum levels of ionised calcium, due to calcium deposition in the bone and this decrease in calcium would tend to stimulate PTH secretion and thereby counteract the expected decrease in PTH with increasing vitamin D,”​ the researchers speculated.

redwinesplash-3x2

Resveratrol is a powerful polyphenol and anti-fungal chemical that is often touted as the bioactive compound in grapes and red wine. Interest in the compound exploded in 2003 when research from David Sinclair and his team from Harvard reported that resveratrol was able to increase the lifespan of yeast cells.

According to Sinclair’s findings, resveratrol could activate a gene called sirtuin1 (Sirt1 – the yeast equivalent was Sir2), which is also activated during calorie restriction in various species, including monkeys.

Other studies with only resveratrol have reported other benefits, including supporting heart health, blood sugar management, and energy endurance enhancement.

“To gain better insight, future studies should include double-labeled bone biopsies useful to determine for example mineral apposition rate and to quantify osteoclasts by tartrate-resistant acid phosphatase (TRAP) staining,​the researchers said.

 

Source:

The Journal of Clinical Endocrinology & Metabolism

October 2014 (DOI: http://dx.doi.org/10.1210/jc.2014-2799​)

Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial​’

Authors: Marie Juul Ornstrup, Torben Harsløf, Thomas Nordstrøm Kjær, Bente Lomholt Langdahl, Steen Bønløkke Pedersen

Related news

Show more

Related products

show more

Expand Your Portfolio with EpiCor

Expand Your Portfolio with EpiCor

Embria Health Sciences | 20-Jan-2020 | Research Study

The next movement in consumer health is fermentation. And as the first-of-its-kind fermentate ingredient that taps the natural power of fermentation to...

Related suppliers

2 comments

Wine vs. Concentrated Sources

Posted by Robert W Tucker,

While I'm not drawing any conclusions about the differences between resveratrol as naturally occurring in wine cf. more concentrated sources, RSV(high) represents only 2-4 capsules at commonly available OTC dosages. The comparison to 90 bottles of wine is a bit of a stretch.

Report abuse

Resveratrol dosage

Posted by Garry Wainscott,

The slightly effective dosage in this study works out to be the equivalent of 90+ BOTTLES of finest quality Australian Shiraz wine per DAY. I therefore do not anticipate much bone mineralization benefit from my two standard drinks of Shiraz per day.

Report abuse

Follow us

Featured Events

View more

Products

View more

Webinars