Caffeine’s neuroprotective effects dependent on genetic makeup, says study

By Oliver Nieburg contact

- Last updated on GMT

Only those with a certain genotype get added protection from Parkinson's Disease by drinking more coffee; others already have built in protection
Only those with a certain genotype get added protection from Parkinson's Disease by drinking more coffee; others already have built in protection
Researchers at Linköping University in Sweden say they have discovered genetic variations in caffeine’s protection against Parkinson’s Disease.

Their study published in the journal PLOS One​ identified a variant of the GRIN2A gene (CC-type) which could protect against Parkinson's when combined with a high caffeine intake through coffee consumption.

It means that those with the gene can boost protection against Parkinson’s Disease (PD) by drinking more coffee. However, those with another variant of the GRIN2A gene (TC type) already have protection and their defence against PD will not be boosted by increased caffeine intake.

Genetic variations

“Caffeine integrates with a dopamine receptor that regulates the flow of calcium into the cell. As dopamine is part of the human reward system, and the interaction of caffeine with it, it has been speculated that individuals with certain genetic variations are not “rewarded” to the same extent by a cup of coffee, and therefore would not enjoy the same protective effect as others. The newly published study shows that GRIN2A can be a part of such a genetic predisposition,”​ said the researchers.

Under the study, the researchers analysed the genetic variants in GRIN2A in 193 PD patients and 377 controls across two counties in south east Sweden. They found differences between those with a CC GRIN2A and a TC GRIN2A genotype.

They distinguished between light (under 237.8 mg/day) or heavy caffeine consumers (over 237.8 mg/day) using questionnaires.

CC and TC types

Those with in the CC group who had a heavy caffeine intake reduced their PD risk by 47% compared to those with a low caffeine intake.

But those with in the TC cohort already had a 47% PD risk reduction regardless of the caffeine dose “Increasing caffeine dose does not have any further additive effects,” ​said the researchers.

However: “...PD susceptible CC genotype carriers can get benefit from increasing amount of caffeine intake for PD risk reduction by 58% with 200–≤400 mg/day, by 80% with 400–≤600 mg/day, and by 79% with >600 mg/day,” ​said the researchers.

Sweden had a high per capita roasted coffee consumption than international standards at 9 kg in 2004. By comparison France had a 4.4 kg rate and the Netherlands 7.1%

Under the study, the CC genotype was the most common. 159 PD patients and 284 in the control group had this genotype compared to 30 (PD) and 88 (control) with a TC genotype. Five in the control group and four in the PD group had an alternative TT genotype.

Source:
PLOS One, 9(6): e99294
DOI: 10.1371/journal.pone.0099294
‘Caffeine Interaction with Glutamate Receptor Gene GRIN2A: Parkinson's Disease in Swedish Population’
Authors: Naomi Yamada-Fowler, Mats Fredrikson,  And Peter Söderkvist

Related topics: Research, Cognitive function

Related news

Show more

Related products

show more

Resveratrol – Revitalizing Cognitive Function

Resveratrol – Revitalizing Cognitive Function

Evolva | 29-Sep-2017 | Technical / White Paper

Cognitive decline is fast becoming the biggest concern of the 65+ population. A population which is set to reach 1.1 billion by 2030*.  · 80% of 60+ take...

Natural, slow-release caffeine by Lipofoods

Natural, slow-release caffeine by Lipofoods

Lipofoods, a Lubrizol Company | 25-Sep-2017 | Data Sheet

Lipofoods presents NEWCAFF™ microcapsules, a natural, slow-release caffeine with a clean non-bitter taste, ideal for sports and nutrition products targeting...

Related suppliers

1 comment

ABA Comment

Posted by American Beverage Association, ABA Communications,

In addition to the fact that caffeine has been safely consumed in foods and beverages for centuries, this study adds to other credible research documenting the potential health benefits of caffeine. In other words, the billions of people who routinely consume caffeine can continue to do so with confidence, and the knowledge that this ingredient may even enhance health.
-American Beverage Association

Report abuse

Follow us

Featured Events

View more

Products

View more

Webinars