Science in brief

Folic acid supplements fail to boost mood in young people

- Last updated on GMT

Folic acid supplements fail to boost mood in young people
Dietary supplements containing folic acid did not improve influence the incidence of mood disorder in young people with an increased familial risk of the condition, says a new study.

Data from epidemiological studies have suggested that low folate levels may increase the risk of depressive symptomatology in the general population leading to the hypothesis that folic acid supplements may influence mood.

However, in a randomized, double blind, parallel group, placebo-controlled trial with 112 young people with an increased familial risk of mood disorder, folic acid supplements at a dose of 2.5 milligrams per day did not significantly affect the incidence of mood disorder.

Data published in the Journal of Affective Disorders​indicated that, “there was post-hoc evidence that folic acid delayed the time to onset of mood disorder in those participants who became unwell.

“In addition, the mood disorders in the folate treated participants, when they occurred, tended to be clinically milder.”

Scientists from Oxford University in England noted that their study was limited by not recruiting the targeted number of subjects, and because the rate of onset of mood disorders was lower than they expected.

“Thus we cannot exclude that a larger participant sample or different experimental design would have shown a significant beneficial effect of folate prophylaxis.”

Source: Journal of Affective Disorders
Volume 167, Pages 306-11, doi: 10.1016/j.jad.2014.06.011
“Folic acid supplementation for prevention of mood disorders in young people at familial risk: A randomised, double blind, placebo controlled trial”
Authors: Sharpley AL, Hockney R, McPeake L, Geddes JR, Cowen PJ.

Related news

Show more

Related products

show more

Resveratrol – Revitalizing Cognitive Function

Resveratrol – Revitalizing Cognitive Function

Evolva | 29-Sep-2017 | Technical / White Paper

Cognitive decline is fast becoming the biggest concern of the 65+ population. A population which is set to reach 1.1 billion by 2030*.  · 80% of 60+ take...

Natural, slow-release caffeine by Lipofoods

Natural, slow-release caffeine by Lipofoods

Lipofoods, a Lubrizol Company | 25-Sep-2017 | Data Sheet

Lipofoods presents NEWCAFF™ microcapsules, a natural, slow-release caffeine with a clean non-bitter taste, ideal for sports and nutrition products targeting...


12 Reasons MenaQ7® is the Superior Vitamin K2

NattoPharma USA, Inc. | 11-Sep-2017 | Data Sheet

Vitamin K2 as MK-7 supplements are truly changing the face of global health, benefiting old and young alike. We know this because NattoPharma has single-handedly...

Related suppliers

Follow us


View more