Science short

Study: Vitamin A form shows breast cancer prevention potential

By Shane Starling

- Last updated on GMT

"It looks like retinoic acid exerts effects on cancer cells in part via the modulation of the epigenome."
"It looks like retinoic acid exerts effects on cancer cells in part via the modulation of the epigenome."
A vitamin A form called retinoic acid that is commonly found in sweet potatoes and carrots, can help turn breast cells showing cancerous potential back to a healthy state, researchers have found.

Writing in the International Journal of Oncology, ​Sandra V Fernandez, PhD, assistant research professor of Medical Oncology at Thomas Jefferson University,​ said vitamin A had not been shown to help those with breast cancer, but in a pre-state, could deliver benefits at particular doses.

"It looks like retinoic acid exerts effects on cancer cells in part via the modulation of the epigenome,"​ she said.

"We were able to see this effect of retinoic acid because we were looking at four distinct stages of breast cancer. It will be interesting to see if these results can be applied to patients."

The in vitro​ study focused on four types of cells: Normal; pre-cancerous; cancerous; fully aggressive.

After retinoic acid was introduced the pre-cancerous cells looked more normal and their genetic signature reverted to a healthy one, with 443 genes reverting to a healthy state.

Fully cancerous cells did not respond to the retinoic acid.

The research was funded by Friends for an Earlier Breast Cancer Test and the Pennsylvania Breast Cancer Coalition.

Source:

International Journal of Oncology

DOI:10.3892/ijo.2014.2354

‘All trans-retinoic acid (ATRA) induces re-differentiation of early transformed breast epithelial cells

Authors: Maria Arisi, Rebecca Starker, Sankar Addya, Yong Huang, Sandra Fernandez.  

Related news

Related products

show more

bayir-bone-and-joint-610x343

Clinical Summary on Key Bone and Joint Ingredients

Bayir Extracts | 02-Nov-2017 | Technical / White Paper

Consumers over 50 are on pace to be one of the fastest-growing demographic groups globally. Research shows that Baby Boomers are concerned about bone and...

KERANAT, the hair loss solution.

KERANAT, the hair loss solution.

Robertet Health & Beauty | 14-Sep-2017 | Technical / White Paper

KERANAT's development is based on an innovative mechanism of action. KERANAT acts directly on the dermal papilla, the biological engine of hair, in...

Related suppliers

Follow us

Products

View more

Webinars