Verisol collagen supplements may offer long-lasting skin elasticity benefits: RCT data


- Last updated on GMT

Verisol collagen supplements may offer long-lasting skin elasticity benefits: RCT data

Related tags: Skin, Skin pharmacology and physiology

Oral supplements of specific collagen peptides may improve skin elasticity by up to 30%, says a new study using Gelita’s Verisol branded ingredient.

The study, published in Skin Pharmacology and Physiology​, is said to be the first clinical trial to demonstrate the efficacy of collagen hydrolysate (Verisol) at a low dosage (2.5 g/day) on skin physiology.

“The results clearly revealed that both dosages (2.5 and 5.0 g) of the specific collagen hydrolysate had a beneficial effect on skin physiology, as indicated by increased skin elasticity after 4 weeks of daily consumption,”​ wrote researchers from the University of Kiel (Germany), the Collagen Research Institute (Kiel, Germany), Skin Investigation and Technology (Hamburg, Germany), and the University of São Paulo (Brazil).

“In contrast to most topically applied substances this positive effect of orally applied collagen hydrolysate on skin health seems to be long-lasting, especially in women over 50 years of age.

“Overall collagen hydrolysate intake over a longer period seems to have a positive impact on skin health. It has to be stated that the demonstrated efficacy refers to the specific collagen peptide composition (Verisol) used in this study and could not be extrapolated to collagen hydrolysate in general.”

High level scientific substantiation

Commenting on the results, Tonja Lipp, Sr. Manager Business Development - Health & Nutrition, Gelita, told NutraIngredients-USA that the company is “excited” ​to see the publication of this data, which supports the beauty claims for the company’s Verisol bioactive collagen peptides ingredient.

“It is rare to have effects on skin improvement substantiated by this level of scientific research,” ​she added.

“Bioactive collagen peptides impact the deeper layers of the skin - the dermis - and, as dermal collagen loss is a major factor of skin aging, the benefits have been more pronounced for women aged 50 or older. These beauty from within benefits can be achieved in a natural way by consuming a 2.5 g daily dose of Verisol, which can be conveniently incorporated into daily lifestyle.

“Consumers now have a healthy and natural addition to traditional topical skin applications,”​ said Lipp.

Study details

Led by Prof Ehrhardt Proksch, MD, PhD, the researchers recruited 69 women aged between 35 and 55 to participate in their double-blind, placebo-controlled trial. The women were randomly were randomly assigned to receive 2.5 g or 5.0 g of Verisol or placebo once daily for eight weeks.

The results showed that skin elasticity, which was the primary endpoint, was improved after four and eight weeks in both collagen hydrolysate groups, compared with placebo, with no statistically significant differences between the collagen groups.

Further analysis revealed that the effects of the collagen supplement skin elasticity were more pronounced in women aged over 50.

“The fact that this positive effect was still detectable at the end of the 4-week washout phase suggests a long-lasting dermal physiological effect,” ​wrote the researchers. “These findings are in contrast to topical products which should be mostly effective in the skin ageing-encountered superficial dermis and epidermis, where improved skin elasticity is predominantly caused by an increase in epidermal hydration.”

On the other hand, no statistically significant effects were observed for skin moisture and skin evaporation, although a “positive influence”​ was observed for skin moisture (improvements of 11 to 14%) and skin evaporation (improvements of 6 to 7%) in women over 50.

Prof Proksch and his co-workers noted that experimental studies with human collagen-producing skin cells (fibroblasts) have shown that the Verisol collagen product may stimulate the expression of skin extracellular matrix macromolecules.

“After supplementation of the collagen peptides to fibroblast cultures a pronounced increase of type I collagen expression as well as in the expression of proteoglycans like biglycan, decorin and versican could be observed,”​ they explained.

“Although further investigations are needed, it could be speculated that the observed positive effect of collagen hydrolysates on skin elasticity might be caused by an increase of dermal matrix macromolecule biosynthesis.”

While the study used the Gelita ingredient, Prof Proksch confirmed that their research is independent.

“A follow up study is accepted for publication and will appear soon,”​ he added.

Source: Skin Pharmacology and Physiology
Volume 27, Pages 47-55, doi: 10.1159/000351376
“Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study”
Authors: E. Proksch, D. Segger, J. Degwert, M. Schunck, V. Zague, S. Oesser

Related news

Show more

Related products

show more

Injuv: Internal Hydration for External Benefits

Injuv: Internal Hydration for External Benefits

Soft Gel Technologies, Inc. | 13-Jun-2018 | Technical / White Paper

Injuv softgels contain a naturally-derived hyaluronic acid (HA) complex with proven bioavailability. A proprietary enzyme-cleaving technique allows it...

IOC: Collagen Supplement are Useful for Athletes

IOC: Collagen Supplement are Useful for Athletes

Gelita AG | 02-Apr-2018 | Technical / White Paper

The IOC concluded that from the many thousands of different products on the market, only a few may provide performance or health related benefits to athletes,...

Crackers from sustainable plant protein and fiber

Crackers from sustainable plant protein and fiber

Roquette America, Inc | 11-Dec-2017 | Data Sheet

Protein rich crackers made from sustainable plant protein pea and fiber:Discover the key benefits of NUTRALYS® pea protein and NUTRIOSE® soluble fiber...


Explore Product Opportunities with Astaxanthin

Solix Algredients, Inc. | 04-Dec-2017 | Research Study

American consumers are taking a more proactive role as managers of their personal health, wellness and nutrition.

So, it's an excellent...

Related suppliers

1 comment

What is the source of collagen?

Posted by brian,

Where is the collagen produced from? And are they in a capsule or tablet form?

Report abuse

Follow us

Featured Events

View more


View more