Ayurvedic salacia herb shows pre-diabetes benefit: Study

By Shane Starling

- Last updated on GMT

Related tags: Nutrition, Diabetes mellitus, Blood sugar

Researchers on Salacia reticulata: "...may be beneficial for maintaining lipids and glucose normal levels..."
Researchers on Salacia reticulata: "...may be beneficial for maintaining lipids and glucose normal levels..."
An ayurvedic herb can manage pre-diabetes states and mild to moderate hyperlipidemia, according to Indian researchers.

For six weeks, 29 subjects received either a placebo and lifestyle therapy or 500mg of Salcital, a branded form of salacia reticulata root bark extract or leaves extract supplied by Indian firm Olive Lifesciences.

Only the Salcital root bark extract group registered a significant reduction in low-density lipoprotein cholesterol and fasting blood sugar (FBS) levels at week 3 and 6. The leaves extract group recorded a reduction only at week 6.

The researchers concluded: “Due to the presence of the a-glucosidase inhibitor ingredient in salacia, patients with prediabetes and mild to moderate hyperlipidemia exhibited improvements in serum lipid profiles and glycemic levels when treated with salacia extracts.”

The randomised, double-blind, placebo-controlled study was led by H.N. Shivaprasad from Olive Biosciences R&D department and was published this month in the Journal of Medicinal Food​.

The randomised, double-blind, placebo-controlled study was led by H.N. Shivaprasad from Olive Biosciences R&D department and was published this month in the Journal of Medicinal Food​.

Active ingredients of Salacia include salacinol, kotalanol, kotalagenin-16 acetate, and mangiferin.

“The active ingredients have a variety of actions, including postprandial glucose decrease by inhibiting a-glucosidases in the intestinal brush border, and thus slowing carbohydrate breakdown into absorbable monosaccharides,”​  the researchers said, in describing potential mechanisms of action.

Pre-diabetes, also known as intermediate hyperglycemia, is a high-risk state for diabetes, with 5-10% of pre-diabetics moving to full diabetics each year.

Pre-diabetics can suffer from hyperlipidemia, hypertension, and insulin resistance-linked obesity.

Source:

Journal of Medicinal Food

June 2013, 16(6): 564-568

‘Salacia reticulata Improves Serum Lipid Profiles and Glycemic Control in Patients with Prediabetes and Mild to Moderate Hyperlipidemia'

Authors: H.N. Shivaprasad, M. Bhanumathy, G. Sushma, T. Midhun, K.R. Raveendra, K.R. Sushma, and K. Venkateshwarlu

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1 comment

Clinical efficacy of Salacia reticulata/ S.oblonga

Posted by Venki Hariharan,

The extract that is standardised to Salicinol and Kotanolol showed marked reduction of hyperglycaemia and it has similar action that of Acarbose. In Phytotech we are conducting a double blind clinical trial to justify this claim.

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