Olive polyphenols play ‘key role’ in learning and memory processes: Animal data

Olive polyphenols play ‘key role’ in learning and memory processes
A natural extract made from olive polyphenols could help to increase learning and memory processes by increasing levels of important proteins in the brain, according to new research in rodents.

The new study, published in Nutrition​, shows that supplementation with olive polyphenols increase levels of the proteins (known as neurotrophins) nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) – both of which play key roles in the development, growth, and survival of brain cells.

Led by Dr Marco Fiore from the Institute of Cell Biology and Neurobiology, Italy, the research team supplemented mice with an olive extract (Phenolea Active Complex, Phenofarm) for ten days before testing whether the polyphenols had an effect on NGF and BDNF content and the expression of their receptors, TrkA and TrkB, respectively, in the mouse brain.

“Polyphenols extracted from olive may increase the levels of NGF and BDNF in the crucial tissues of the mouse limbic system and in the olfactory bulbs, brain areas playing a key role in learning and memory processes, and in the regulation of the proliferation and migration of endogenous neuronal stem cells present in the mammalian brain,”​ said the research team.

“To our knowledge, this is the first study to demonstrate in a mouse model that a mixture of polyphenols extracted from olive pomace, obtained in the process of extra virgin olive oil production, may have effects on NGF/BDNF levels in selected brain areas,”​ they added.

Research details

Fiore and his colleagues noted that various studies have suggested that dietary polyphenols can help to protect against cancer and cardiometabolic and neurodegenerative diseases, however very few have investigated their effect on the development or protection of cognitive functions.

“Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neurotrophins that play key roles in brain cell development, growth, and survival,”​ they said.

The team supplemented mice with either 10 mg/kg of polyphenols extracted from olive residues (six mice) or a control diet (six mice) for ten days, before measuring the effects of the intervention on biomarkers in the blood and certain brain regions.

“We found NGF and BDNF elevation in the hippocampus and olfactory bulbs and a decrease in the frontal cortex and striatum,”​ revealed the authors – who added that the findings were associated with increased expression of TrkA and TrkB receptors in the hippocampus and olfactory bulbs but not in the striatum and frontal cortex.

“Altogether, this study shows that olive polyphenols in the mouse may increase the levels of NGF and BDNF in crucial areas of the limbic system and olfactory bulbs, which play a key role in learning and memory processes,”​ concluded Fiore and his team.

Source: Nutrition
Volume 29, Issue 4​, Pages 681–687, doi: 10.1016/j.nut.2012.11.007
Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain”
Authors: Sara De Nicoló, Luigi Tarani, Mauro Ceccanti, Mariateresa Maldini, et al

Related topics Research Polyphenols Botanicals

Related news

Show more

Related products

show more

ACTRISAVE™ NATURAL SUPPORT FOR SKIN AND MALE HAIR

ACTRISAVE™ NATURAL SUPPORT FOR SKIN AND MALE HAIR

Content provided by BIONAP BIOACTIVE NATURAL PRODUCTS | 30-Sep-2024 | Product Brochure

ACTRISAVE™ is a powdered extract obtained from the patented association between black rice (Oryza sativa L.) and the flowers of prickly pear (Opuntia ficus-indica...

Tackling Metabolic Health with HIMABERB® Berberine

Tackling Metabolic Health with HIMABERB® Berberine

Content provided by Pharma Base S.A. | 18-Sep-2024 | White Paper

Metabolic health is a prevalent and rapidly growing global challenge. In recent years, there has been mounting clinical evidence to support the use of...

Fast acting Specialty Lutein Esters

Fast acting Specialty Lutein Esters

Content provided by Ennature Biopharma, a Division of India Glycols Limited | 16-Sep-2024 | Case Study

Xanthogreen® is a clinically validated, clean label ingredient from marigold flowers that helps boost your eye health with visible effects in as little...

Healthy “SHE” for  Healthy Family

Healthy “SHE” for Healthy Family

Content provided by Chemical Resources (CHERESO) | 12-Sep-2024 | White Paper

SheVari4T standardised to Shatavarin IV is Known for its medicinal properties, and has been tailored specifically for women's self-care needs, offering...

Related suppliers

Follow us

Products

View more

Webinars