Probiotics may ease stress-related gut problems: Mouse data

By Stephen DANIELLS

- Last updated on GMT

Related tags: Bacteria, Gut flora

Probiotics may ease stress-related gut problems: Mouse data
A supplement of beneficial bacteria may ease stress-induced intestinal inflammation for people with irritable bowel syndrome, suggests new data from the University of Michigan.

Lab mice with water-avoidance stress (WAS)-induced intestinal disorders were associated with a suppressing an important component called an inflammasome which is needed to maintain normal gut microbiota.

However, a commercial probiotic supplement containing Bifidobacterium bifidum​, Lactobacillus acidophilus​, and Streptococcus faecalis​ was found to significantly reduce the severity of gut flare-up, and reversed changes in the microbiota that WAS caused, according to findings published in Gastroenterology​.

“The effect of stress could be protected with probiotics which reversed the inhibition of the inflammasome,”​ said John Kao, MD, associate professor of internal medicine at the University of Michigan and senior author.

“This study reveals an important mechanism for explaining why treating IBS patients with probiotics makes sense.”

According the FAO/WHO, probiotics are defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host"​.

Study details

Kao and his co-workers examined the effects of stress on the composition of gut bacteria, and the potential beneficial role of probiotics.

The data indicated that stressed mice produced a substance called corticotropin-releasing hormone (CRH) that inhibited NLRP6 inflammasome activity.

However, feeding the animals probiotic supplements prior to the induction of stress reduced inflammation.

“These findings might explain the benefits of probiotics for patients with stress-associated gastrointestinal disorders,” ​wrote the researchers.

Kao said that additional clinical studies are required to determine the optimal probiotic therapy.

“Patients can start living healthier lifestyles to improve their gut microbiota such as adding more fruits and vegetables to their diet, and looking for ways to keep stress in check.”

Source: Gastroenterology
Published online ahead of print, doi: 10.1053/j.gastro.2013.02.038
“Stress-Induced Corticotropin-Releasing Hormone-Mediated NLRP6 Inflammasome Inhibition and Transmissible Enteritis in Mice”
Authors: Y. Sun, M. Zhang, C-C. Chen, M. Gillilland III, X. Sun, M. El-Zaatari, G.B. Huffnagle, V.B. Young, J. Zhang, S-C. Hong, Y-M. Chang, D.L. Gumucio, C. Owyang, J.Y. Kao

Related news

Show more

Related products

show more

The CBD opportunity is waiting…are you ready?

The CBD opportunity is waiting…are you ready?

DSM Nutritional Products | 04-Oct-2021 | Infographic

CBD is set to shake up the dietary supplements industry. And with DSM as your end-to-end partner, you can be at the forefront of CBD innovation.

Absocurcumin® - A Botanic Joint Health Ingredient

Absocurcumin® - A Botanic Joint Health Ingredient

BOTANIC HEALTHCARE (NZ) LTD | 02-Sep-2021 | Clinical Study

ABSOCURCUMIN® is a clinically proven standardized phytochemical composition derived from Turmeric, Curcuma longa. In a controlled study of 30 adults aged...

New Postbiotic for a Healthy Gut and Thriving Body

New Postbiotic for a Healthy Gut and Thriving Body

Blue California | 09-Aug-2021 | Technical / White Paper

The postbiotic butyrate may have many well-established health benefits, which support the gut, brain, and immune health, but has had limited adoption due...

Related suppliers

Follow us

Products

View more

Webinars