GliSODin may protect against severe oxidative stress

Related tags Superoxide dismutase Oxidative stress Dna damage

Researchers at the University of Ulm in Germany have received
encouraging results from a study into the potential for GliSODin
supplementation to protect against oxidative DNA damage related to
ischemia-reperfusion, an injury caused by a sudden reduction in
blood flow that can be a concern during surgery.

Distributed in the United States by PL Thomas, GliSODin is promoted as a supplement to boost the internal antioxidant defense system of humans. It contains superoxide dismutase (SOD), an enzyme contained in every cell of the body that is thought to protect them against oxidative damage, and the wheat-derived bioactive compound gliadin.

In the study entitled 'The orally effective mixture of SOD and gliadin (GliSODin) protects against oxidative DNA damage'​, swine were given either GliSODin supplements or a placebo prior to the induction of ischemia-reperfusion.

By measuring DNA damage before and after surgery, scientists were able to ascertain that the GliSODin group suffered less oxidative DNA damage than the placebo group, while isoprostane levels, another marker of oxidative stress, increased in the placebo group, but not in the GliSODin group.

An earlier double-blind, placebo-controlled clinical trial published in Free Radical Research​ in September 2004 showed that GliSODin protects against induced oxidative damage with just two weeks of supplementation.

"These results led the researchers to investigate whether GliSODin is also protective when during more severe oxidative stress, as in induced ischemia-reperfusion,"​ PL Thomas' Eric Anderson told​.

"This study is very powerful in that a protective benefit was demonstrated in severe circumstances,"​ he added. "If these types of results are shown in human studies, GliSODin's therapeutic benefits have great potential."

Related topics Research Cardiovascular health

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