Aged garlic tested for antioxidant properties
have investigated the effect of dietary supplementation with aged
garlic extract (AGE) on blood plasma and urine concentrations of
F2-isoprostanes, well known indicators of lipid peroxidation.
Researchers from Liverpool Sir John Moores University in the UK have investigated the effect of dietary supplementation with aged garlic extract (AGE) on blood plasma and urine concentrations of F2-isoprostanes, well known indicators of lipid peroxidation.
The researchers from the University's School of Biomolecular Sciences, studied whether AGE affected concentrations of F2-isoprostane 8-iso-prostaglandin F2 (8-iso-PGF2) in plasma and urine.
Both smokers and non-smokers were tested, as smokers generally suffer from higher levels of oxidative stress. The researchers used Kyolic, an AGE supplement made by Wakunaga of America.
Plasma and urine concentrations of 8-iso-PGF2 in non-smoking individuals were 1.25 plus or minus 0.19 nmol/L and 272 plus or minus 53 pmol/mmol of creatinine respectively. In age- and sex-matched smokers, plasma and urine concentrations of 8-iso-PGF2 were 58 per cent and 85 per cent higher respectively.
The study showed that dietary supplementation with AGE for 14 days reduced plasma and urine concentrations of 8-iso-PGF2 by 29 per cent and 37 per cent in non-smokers and by 35 per cent and 48 per cent in smokers.
However, 14 days after the supplements were stopped, both plasma and urine concentrations of 8-iso-PGF2 in both groups returned to roughly the same levels as before the study began.
