Bitter Orange

Study finds no fat burning effect of p-synephrine in healthy active women

07-Nov-2022 By Asia Sherman

Bitter orange extract p-synephrine had no effect on fat oxidation rate during aerobic exercise in healthy active women, according to a recent study from university researchers in Spain.

FDA study finds hidden synthetic ingredients, poor quality control in bitter orange supplements

17-Jun-2020 By Hank Schultz

A US Food and Drug Administration study reveals that a number of the products it tested labeled as ‘bitter orange’ did not meet label claim for synephrine content and more than 10% contained undeclared synthetic ingredients.

Bitter Orange Extract: Still safe, researcher reasserts in new review

01-Aug-2017 By Adi Menayang

Thirteen years have passed since the FDA banned ephedrine. Ever since, bitter orange extract, which has an active compound structurally similar to ephedrine (p-synephrine) has been under scrutiny. A new scientific review looks at the most recent clinical...

RCT supports cardiovascular safety of Bitter Orange in healthy people

12-May-2016 By Stephen Daniells

Consuming extracts of bitter orange extracts do not (Citrus aurantium) do not detrimentally affect measures of heart function in healthy people, says a new double-blinded, placebo-controlled cross-over study.

‘An interesting interpretation’: Does a concentrate of an ODI need an NDI?

24-Nov-2015 By Stephen Daniells

A concentrate of an old dietary ingredient may need to file a new dietary ingredient notification, according to a new warning letter from the US Food and Drug Administration about bitter orange. 

Finnish synephrine ban ‘based on unsubstantiated conjecture’: Academic

02-Oct-2013 By Shane STARLING

A dossier of scientific data that convinced Health Canada and Intertek Cantox of the safety of bitter orange extract, synephrine, has been sent to Finnish authorities which recently banned weight loss products containing the stimulant, along with caffeine.

Finland warns against synephrine and caffeine combo fat burners

09-Sep-2013

Fat burning food supplements containing a combination of caffeine and synephrine are dangerous, according to Finnish authorities which have called for their removal from shelves.

Letter to the editor

Nutratech: BfR report is ‘clearly at odds with the scientific literature on safety of bitter orange-caffeine combinations’

10-Apr-2013

Leading bitter orange/ p-synephrine supplier Nutratech has countered a report from the German Federal Institute for Risk Assessment (BfR) over concerns about the ingredient’s safety, noting it is at odds with the scientific literature.

Bitter orange and caffeine combo may be unsafe, says BfR

09-Apr-2013 By Nathan Gray

Sports supplements and weight loss products that contain a combination of caffeine and synephrine from bitter orange may not comply with current regulations and could be classified as unsafe, warns the BfR.

Human data supports bitter orange/ p-synephrine safety in humans: Nutratech

30-Jan-2013 By Stephen DANIELLS

Extracts from bitter orange (Citrus aurantium) on its own or combined with naringin and hesperidin do not pose any risks at doses commonly used by humans, says new data from a 60 day, double-blinded, placebo-controlled trial.

Bitter orange/ synephrine safety gets new review support

18-Sep-2012 By Stephen Daniells

Extracts from bitter orange on its own or combined with caffeine do not pose any risks at doses commonly used by humans, says a new review of published and un-published clinical data.

Industry can be confident in bitter orange safety, says Nutratech

28-Aug-2012

The dietary supplements industry can be confident in the safety of bitter orange extracts, and the p-synephrine they contain, despite a new analysis from FDA raising concerns over heart rate and blood pressure, says Nutratech Inc.

Bitter orange extract may raise blood pressure and heart rate: FDA analysis

27-Aug-2012 By Stephen Daniells

A multi-component extract of bitter orange (Citrus aurantium) may raise blood pressure and heart rate in lab animals, says new data from the US Food and Drug Administration (FDA).

Nutratech reports surge in interest in bitter orange as firms seek to replace DMAA

06-Jul-2012 By Elaine Watson

Nutratech - the firm behind patented bitter orange (Citrus aurantium) extract Advantra Z - has seen a surge in enquires from manufacturers looking for alternatives to DMAA in the wake of the FDA’s crackdown on the controversial stimulant.

Health Canada eases guidelines on p-synephrine from bitter orange

02-Nov-2011 By Stephen Daniells

Guidelines for us of p-synephrine, the predominant alkaloid in bitter orange, has been redefined by Health Canada, with 1 to 50 mg per day of the compound now classified as not ‘likely to cause any adverse health consequences’.

FDA data supports bitter orange safety

15-Jun-2011 By Stephen Daniells

High doses of bitter orange (Citrus aurantium) are not toxic to mothers or their babies, according to a new toxicology study with rats from FDA that adds to the ingredient’s safety profile.

Citrus extracts show energy burning potential, without side effects: Study

17-May-2011 By Stephen Daniells

Bitter orange extracts plus the citrus flavonoids, naringin and hesperidin, may boost metabolic rates without affecting blood pressure, says a new study with implications for weight management.

Bitter orange concerns ‘unwarranted and unjustified’: Review

19-Nov-2010 By Stephen Daniells

Safety concerns and adverse events associated with bitter orange, and the p-synephrine compound it contains, are ‘unwarranted and unjustified’, according to a review of FDA’s reports.

Bitter orange standard developed amid safety concerns

14-May-2008 By Shane Starling

A new standard has been published for the weight loss herb bitter
orange that will allow interested parties to "develop and test
analytical methods for compounds in bitter orange".

Nutratech settles with Syntech over patents

22-Oct-2007 By Clarisse Douaud

Another patent infringement case has been settled between two
nutraceutical ingredient companies - this time involving Nutratech
and Syntech International over the use of citrus aurantium
extract.

Nutratech tests Advantra Z for blood pressure risk

28-Jul-2005

Nutratech is reassuring the industry that its bitter-orange based
ingredient Advantra Z does not contain meta-synephrine, an isomer
that has the potential to raise blood pressure, following testing
at an independent laboratory.

The post-ephedra weight loss market

21-Jul-2005

The herbal supplements industry could be losing interest in weight
loss, judging by the drop off in product launches since the start
of 2005, writes Jess Halliday.

Seville orange row refuses to blow over

08-Sep-2004

The debate over the safety of citrus aurantium rumbles on, with the
American Herbal Products Association (AHPA) adding its voice to the
industry backlash against a review article published last week
which suggested that the use of...

Ephedra alternative gets patent in Canada

23-Jun-2004

Nutraceutical ingredient supplier Nutratech has received a Canadian
patent for Advantra Z, a product it sees as a safe successor to the
banned herbal product ephedra.

Nutratech fights for bitter orange claims

27-Jan-2004

New Jersey-based Nutratech has settled its lawsuit concerning use
of claims related to its bitter orange brand.

Nutratech defends ephedra alternative patent

25-Sep-2003

Nutraceutical ingredient supplier Nutratech has filed a patent
infringement lawsuit against Nutrabiotics Research Labs for making
unfounded claims for a generic version of Nutratech's ephedra
alternative Advantra Z Citrus aurantium.