Patented Kolla2® for Joint Health

Kolla2® is a joint health supplement made from chicken sternum. It is specially manufactured with a patented process (US Patent #6,838,440) that produces denatured Collagen Type II chains. In addition, Kolla2® contains important glycosaminoglycans (GAGs), including chondroitin sulfate and hyaluronic acid.

Cartilage​

Cartilage is a matrix composed mainly of collagens and proteoglycan aggregates. The main cartilage collagen is Collagen Type II. The cartilage proteoglycan aggregates consist of a long spine of hyaluronic acid and many proteoglycan monomers non-covalently bound to the hyaluronic acid spine through two linker proteins. Proteoglycans are composed of long glycosaminoglycan (GAG) chains covalently linked to a core protein. The linker proteins bind to both the core protein of the proteoglycan and to the hyaluronic acid chain, thereby stabilizing the aggregate. GAG has long unbranched chains composed of repeating disaccharide units. One of the two sugars is always an amino sugar, either N-acetyl-D-glucosamine or N-acetyl-D-galactosamine. In cartilage, GAGs are mainly chondroitin sulfate and keratan sulfate.

Glucosamine exists in the form of N-acetyl D-glucosamine, which is an important component of GAG.

Collagens​

Collagen is a triple helix of polypeptide chains. Each polypeptide chain usually has about 1000 amino acids. Analysis of the polypeptide chains reveals that glycine and proline or hydroxyproproline are very prominent. Almost one third of the amino acids are glycine and one quarter is proline or hydroxyproline. Most of the polypeptide chain is a repeating unit of the tripeptide glycine-X-proline, where X is another amino acid and proline can be hydroxyproline.

The polypeptides assume a left-handed helix conformation. This structure enables the 3 helices to interlock better to form a rigid 3-stranded cable or triple helix.

There are fourteen types of known collagens in our body. The most important ones are Types I, II, III and IV. Types I & III coexist in skin. In cartilage, Type II is predominant. However, the ratio of Type II Collagen to other collagens differs in different types of cartilage.

Kolla2​® for Joint Health​

Kolla2® is made from chicken sternum and contains all the important components of cartilage: collagens and GAGs (chondroitin, hyaluronic acid and keratan). Type II collagen accounts for 90-95% of all collagen in sternum cartilage, which is very similar to the compositions of collagen in human joint cartilage. As we age, the body's ability to make collagen proteins and GAGs slows down. Supplementing with Kolla2® replenishes the body's supply.

Supplying building blocks of cartilage for joint health has been shown to be effective in numerous studies. Glucosamine and chondroitin are examples of such successful supplements. Thus, collagen may provide additional benefits to joint health.

Chondroitin is only one piece of the puzzle. Supplementing with Kolla2®, which contains all the cartilage-building components (including Collagen Type II and GAGs) and cartilage stimulating elements, provides the complete cartilage solution.

Kolla2® is a natural solution to joint care.

Source of Collagen Type II in Kolla2​®

The most cost effective source of Collagen Type II is young chicken sternum cartilage. In sternum, the predominant collagen is Type II (over 90% of the sternum collagen). The content of total protein (mainly collagen) is over 65%. The rest is mainly chondroitin, hyaluronic acid, and keratan.

Quality Control​

Product quality and consistency is always of great importance. Kolla2® is manufactured in a GMP facility under strict quality control standards. Special equipment has been installed to guarantee low heavy metals and lead. The Kolla2® manufacturing process has been validated through SDS-PAGE gel, enzymatic digestion, ELISA, and other analytical methods in-house and through independent labs. We use FT-NIR on every batch to identity-check the product and to verify that it is made consistently.

Conclusions​

Extensive research has shown that Type II collagen is lost progressively, along with mucopolysaccharides, in rheumatoid and osteoarthritis patients. Osteoarthritis is the most common form of arthritis affecting more than 40 million Americans. It is characterized by joint degeneration, loss of cartilage, alterations of subchondrial bone and damage to the extra-cellular matrix. Taking a Kolla2® supplement, which contains all the important components of the extra-cellular matrix, may help slow down or reverse the process.

Kolla2® offers the complete building blocks for cartilage and a unique advantage as a nutritional supplement product for joint health.
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