Conducting a clinical trial in the health nutrition industry can be an intimidating process. In an extremely competitive market, the company and the products must be able to withstand the heightened scrutiny that accompanies this industry. Clinical research must be conducted to substantiate product claims and gain consumer confidence. Where to go? What to expect? How much will it cost? This paper will address various industry concerns like regulatory environments, claims substantiation, and misconceptions of clinical trials and information on making claims.