Orange polyphenols fail to show immune effects

By Stephen Daniells

- Last updated on GMT

Related tags: Orange juice, Natural killer cell, Immune system

Orange polyphenols fail to show immune effects
Polyphenols from orange juice, and the juice itself, do not affect parameters of immune health, says a new human trial from France.

Researchers from the Université d'Auvergne report that four weeks of orange juice consumption  or a beverage containing the polyphenolic compound hesperidin had no impact on immune markets in 24 volunteers.

“The lack of response to orange juice and/or hesperidin by a healthy population is a positive result because it demonstrates that an inappropriate immune response is not present with the consumption of these treatments,” ​wrote the researchers in Clinical Nutrition​.

“We show that consumption of hesperidin, within the usual daily intake range, do not induce immunomodulation in healthy well-nourished volunteers.”

The French researcher recruited 24 volunteers to participate in the study. Participants had three four-week intervention periods separated by three-week wash-outs. The volunteers consumed either orange juice (500 ml per day), a control beverage with a hesperidin supplement (292 mg per day), or the same control beverage with a placebo.

Results showed no change on any markers of immune health, including B and T lymphocytes, NK cells and monocytes.

“We show that consumption within the usual daily intake range of orange juice and its major polyphenol hesperidin do not induce immunomodulation of cell immune function in healthy well-nourished humans,” ​concluded the researchers.

Source: Clinical Nutrition
Published online ahead of print, doi: 10.1016/j.clnu.2013.03.012
“Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans”
Authors: O. Perche, J. Vergnaud-Gauduchon, C. Morand, C. Dubray, A. Mazur, M-P. Vasson

Related topics: Research, Botanicals

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