MSM, glucosamine combo have faster effect on arthritis

- Last updated on GMT

Related tags: Glucosamine, Osteoarthritis, Msm

Combining the sulphur-containing nutrient MSM with well-known joint
health supplement glucosamine appears to speed up the
anti-inflammatory effect and further reduce pain in patients with
osteoarthritis, report Indian researchers.

Glucosamine, derived largely from shrimp shells, is widely used by arthritis patients but it is less commonly found in combination with MSM, or methylsulfonylmethane, which is the isoxidised form of dimethyl-sulfoxide (DSMO).

It is however often taken along with chondroitin sulphate.

In the new study, both glucosamine and MSM improved osteoarthritis symptoms in subjects but when taken together the effect was greater than either alone.

"Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents,"​ report the researchers in the June issue of Clinical Drug Investigations​ (vol 24, no6, pp 353-363).

More than 7 million adults in the UK - 15 per cent of the population - have long-term health problems due to arthritis and related conditions, according to the Arthritis Research Campaign, and 550,000 have moderate to severe osteoarthritis in their knees.

And across Europe the number of arthritis sufferers will continue to escalate as the population ages and other major risk factors, such as obesity, also increase.

Dr P Usha and M Naidu from Nizam's Institute of Medical Sciences in Hyderabad, India randomised 118 people with mild to moderate osteoarthritis to receive either 500mg glucosamine, 500mg MSM, a combination of both or placebo capsules three times daily for 12 weeks.

Patients were evaluated at prior to the study and several times during treatment for efficacy and safety.

After 12 weeks, the average pain score had fallen from 1.74 to 0.65 in those taking only glucosamine. In MSM-only participants, it fell from 1.53 to 0.74. However, in the combination group, it fell from 1.7 to 0.36.The researchers also found that the combination treatment had a faster effect on pain and inflammation compared to glucosamine alone.

"It can be concluded that the combination of MSM with glucosamine provides better and more rapid improvement in patients with osteoarthritis,"​ write the researchers.

Related topics: Research, Minerals

Related news

Show more

Related products

Gemini Pharmaceuticals and Transparency

Gemini Pharmaceuticals and Transparency

Gemini Pharmaceuticals | 27-Feb-2019 | Application Note

A Brand Owner is 100% responsible for the quality of their products - not the Contract Manufacturing Organization. This is exactly why Gemini Pharmaceuticals...

Clean Label Dietary Supplements - One Perspective

Clean Label Dietary Supplements - One Perspective

Gemini Pharmaceuticals | 01-Feb-2019 | Technical / White Paper

“Clean Label” seems to be all the rage these days. But what does it mean? With no clear regulatory definition, a vacuum has been created where each dietary...

New Dietary Supplement: Get it Right the First Time!

New Dietary Supplement: Get it Right the First Time!

Gemini Pharmaceuticals | 23-Oct-2018 | Technical / White Paper

The Contract Manufacturer and Brand Owner need to establish a process to facilitate the development of new dietary supplement products. It needs to be...

The Most Bioavailable, Organic Form of Magnesium

The Most Bioavailable, Organic Form of Magnesium

Albion Human Nutrition | 22-Jan-2015 | Research Study

Magnesium is required by over 360 biochemical functions in the body, from energy production to sleep. But, it has little benefit if the body cannot tolerate...

Related suppliers

Follow us

Featured Events

View more


View more