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"Eat saffron and you will learn to smile again!" This Persian saying illustrates the widely held folk belief of the benefits of this herbal ingredient whose uses are still generally unexplored within the confines of traditional medicine. In fact, while its use as a taste enhancing spice is quite familiar, saffron is also used to treat certain physical and mental disorders in many Middle Eastern and Asian cultures. However, recent research tends to confirm the efficacy of saffron extracts in the alleviation and prevention of depression and other mood disorders, establishing an interesting perspective in the field of dietary supplements.