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Research reveals Pycnogenol®, French maritime pine bark extract, and Coenzyme Q10 taken as an adjunct to medication naturally strengthens the heart in stable heart failure patients. Published in Panminerva Medica, the study found that after supplementing with a combination of Pycnogenol® and Coenzyme Q10, patients experienced increased blood volume output, improved physical fitness and blood pressure, as well as heart and respiratory rate.