A 16 human subjects study whom consumed 2 grams of BioCell Collagen II daily during an 8 week period provided significant improvement over placebo and was safely tolerated. (Sheldon, E “A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II (BioCell Collagen II®) in adults with osteoarthritis,” Miami Research Associates. April 25, 2003.) Several high molecular weight purified HA products have recently entered the market despite the lack of published human clinical studies to support oral efficacy. BioCell Collagen II appears to be the only HA containing product with a published human clinical study for efficacy
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