SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - North AmericaEU edition

Trends > Probiotics

New models hold promise for probiotic claim substantiation

By Nathan Gray+

29-Nov-2012
Last updated on 29-Nov-2012 at 14:35 GMT2012-11-29T14:35:57Z

Challenge models hold promise for probiotic claim substantiation

Exposing healthy people to modified pathogens in a controlled clinical trial setting could be an exciting new way for industry to overcome the challenges of health claim substantiation, says Nizo Food Research expert.

Probiotics have been a hot topic of late, with attempts to gain EFSA approved health claims causing a number of headaches for the sector.

However, Alwine Kardinaal, senior researcher for health and nutrition at Nizo Food Research believes new challenge models that expose healthy participants to modified versions of pathogens show great promise in elucidating the positive health effects of probiotics.

“EFSA does not accept that there are good or bad bacteria, but they do accept that claims should focus on resistance against pathogens,” explained Kardinaal. “The problem is that there are not very good markers for this.”  

“What is necessary to substantiate a claim in this area is to look at clinical symptoms caused by pathogens, and that is not an easy answer.”

“you need people to get infected”

Kardinaal said that one of the key challenges for industry is that they need to be able to show a positive effect in the target population for the product that will bear the claim – healthy people.

“That means that you need people to get infected,” she said. “There are a number of models that you can think of to do the trick.”

The Nizo expert said while models of spontaneous infection can work, in which people who may be more likely to become ill often are studied, there is an issue with the spontaneous nature of the infections that may occur.

“The problem with such studies is that you don’t know upfront who is going to get infected and who is not. So these typse of studies require quite a large number of study participants which makes them relatively expensive and complex.

A potential solution to this, she noted, is to perform what is essentially a randomised clinical trial by exposing healthy individuals to a pathogen in a controlled way.

“That is a model that we have used in a number of situations,” said Kardinaal. “It can be used to show effects on resistance against pathogens of probiotics, prebiotics, but other ingredients as well.”

Related products

Review: B vitamins, the brain (& deficiencies)

Review: B vitamins, the brain (& deficiencies)

Dr David Kennedy

director of the Brain, Performance and Nutrition Research Centre ,...

Functional & sparking bottled water sales are “very hot in the US”

Functional & sparking bottled water sales are “very hot in the US,” analyst says

Once considered boring by many Americans, water is becoming a go-to beverage of choice...

CV Sciences forges ahead with CBD development

CV Sciences forges ahead with CBD development despite regulatory uncertainties

Ground breaking CBD firm CV Sciences is seeking to shed the stigma of what...

Work on soil improvement leads to mineral ingredient for supplements

Work on soil improvement leads to mineral ingredient for supplements

Work in organic agriculture led Mineral Biosciences to the development of a “fossil mineral”...

NOW Foods CEO: Transparency is key facet of brand equity

NOW Foods CEO: Transparency is key facet of brand equity

Transparency has become a watchword among dietary supplement companies. Jim Emme, president of NOW...

The rise of adaptogenic herbs: ‘These herbs help mitigate stress & we live in a stressful environment’

The rise of adaptogenic herbs: ‘These herbs help mitigate stress & we live in a stressful environment’

Interest in adaptogenic herbs is increasing, but how does industry communicate the benefits to...

Turmeric, matcha & mushroom among specialty teas driving sales

Turmeric, matcha & mushroom among specialty teas that are engaging Millennials and driving sales

Sales of tea in the US continue to climb steadily, thanks in part to...

FDA should focus on tainted products, GMPs, NDIs

FDA’s new dietary supplement office should focus on tainted products, GMPs & NDIs, industry leaders say

With the recent elevation of dietary supplement oversight from a division to its own...

How should mainstream retailers merchandise 'natural' foods?

How should mainstream retailers merchandise 'natural' foods?

How best to merchandise 'natural' foods? For some mainstream food retailers, a store within...

The ‘next generation’ of digestive health drinks? Rhythm tunes into consumer trends

The ‘next generation’ of digestive health drinks? Rhythm tunes into consumer trends

Rhythm Health believes its coconut-based kefir beverages and snacks can be the ‘natural successor’...

Overcoming the taboo of vaginal health – the next frontier of probiotics

Overcoming the taboo of vaginal health – the next frontier of probiotics

A paradigm shift is needed to force delicate women’s health issues like vaginal infections...

Lab meat, plant proteins and insects: Which alternative proteins will feed the world?

Lab meat, plant proteins and insects: Which alternative proteins will feed the world?

The quest for alternatives to animal-derived proteins has led to a huge amount of...

African probiotic project reaching 10,000 infants a day

African probiotic project reaching 10,000 infants a day

Professor Gregor Reid

Chair , University of Western Ontario & Human Microbiology and...

UK researcher backs supplements for omega-3 intakes

UK researcher backs supplements for boosting omega-3 intakes

Philip Calder

Professor, University of Southamption

‘You think Red Bull’s just gonna roll over? It’s not gonna happen!’

‘You think Red Bull’s just gonna roll over? It’s not gonna happen!’ Expert warns wannabes

Beverage brand development guru James Tonkin has warned wannabe entrepreneurs that going up against...

Coffee may hydrate athletes just like water: Researcher

Coffee may hydrate athletes just like water: Researcher

Sophie Killer

Doctoral researcher, Loughborough University

Caffeine in small doses and during training may boost performance

Caffeine taken during training and even in small doses may boost sports performance: Researcher

Sophie Killer

Doctoral researcher in exercise metabolism and performance nutrition

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Professor John Cryan

Chair and head of the Department of Anatomy and Neuroscience,...

Algatech: Functional food on astaxanthin horizon

Algatech: Functional food on astaxanthin horizon

Israeli firm Algatechnologies will work towards gaining approval for its astaxanthin as a novel...

On demand Supplier Webinars

Brain performance – when does it peak and what can we do about it?
Kemin Human Nutrition & Health
The NutraIngredients-USA Omega-3 Forum
William Reed Business Media
All supplier webinars