Breaking News on Supplements & Nutrition - North AmericaEU edition

Trends > Probiotics

Loading...

New models hold promise for probiotic claim substantiation

By Nathan Gray+

29-Nov-2012

Exposing healthy people to modified pathogens in a controlled clinical trial setting could be an exciting new way for industry to overcome the challenges of health claim substantiation, says Nizo Food Research expert.

Probiotics have been a hot topic of late, with attempts to gain EFSA approved health claims causing a number of headaches for the sector.

However, Alwine Kardinaal, senior researcher for health and nutrition at Nizo Food Research believes new challenge models that expose healthy participants to modified versions of pathogens show great promise in elucidating the positive health effects of probiotics.

“EFSA does not accept that there are good or bad bacteria, but they do accept that claims should focus on resistance against pathogens,” explained Kardinaal. “The problem is that there are not very good markers for this.”  

“What is necessary to substantiate a claim in this area is to look at clinical symptoms caused by pathogens, and that is not an easy answer.”

“you need people to get infected”

Kardinaal said that one of the key challenges for industry is that they need to be able to show a positive effect in the target population for the product that will bear the claim – healthy people.

“That means that you need people to get infected,” she said. “There are a number of models that you can think of to do the trick.”

The Nizo expert said while models of spontaneous infection can work, in which people who may be more likely to become ill often are studied, there is an issue with the spontaneous nature of the infections that may occur.

“The problem with such studies is that you don’t know upfront who is going to get infected and who is not. So these typse of studies require quite a large number of study participants which makes them relatively expensive and complex.

A potential solution to this, she noted, is to perform what is essentially a randomised clinical trial by exposing healthy individuals to a pathogen in a controlled way.

“That is a model that we have used in a number of situations,” said Kardinaal. “It can be used to show effects on resistance against pathogens of probiotics, prebiotics, but other ingredients as well.”

Related products

Cargill rides publicity wave with Trehalose functional ingredient

Cargill rides publicity wave with Trehalose functional ingredient

Cargill has weathered a potential media storm concerning its functional ingredient Trehalose.  The ingredient,...

Particulars of GRAS process leave it open to criticism, expert says

Particulars of GRAS process leave it open to criticism, expert says

The GRAS process as it stands in the United States is vulnerable to criticism...

Video: In light of FDA's reticence, professional help critical in NDI submissions

Video: In light of FDA's reticence, professional help critical in NDI submissions

The submissions of New Dietary Ingredient notifications seems as fraught as ever, and part...

Keeping it clean: 3 botanical chiefs pull adulteration weeds

Keeping it clean: 3 botanical chiefs pull adulteration weeds

Antoine Bily, Naturex global R&D director

Christian Artaria, Indena marketing director, Holger Riemensperger, Frutarom general manager,...

Diet and cancer: Polyphenol trial data suggests significant clinical benefit for prostate cancer

Diet and cancer: Polyphenol trial data suggests significant clinical benefit for prostate cancer

Professor Robert Thomas

Consultant oncologist, Addenbrooke's and Bedford, Cambridge University Hospital

Are doctors seeing the preventative eye health potential of carotenoids?

Are doctors seeing the preventative eye health potential of carotenoids?

James Stringham

Research doctor, University of Georgia

Natural and synthetic astaxanthin are different products, Algatech exec says

Natural and synthetic astaxanthin are different products, Algatech exec says

The natural vs synthetic astaxanthin debate centers on the fact that the products are...

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Professor John Cryan

Chair and head of the Department of Anatomy and Neuroscience,...

Algatech: Functional food on astaxanthin horizon

Algatech: Functional food on astaxanthin horizon

Israeli firm Algatechnologies will work towards gaining approval for its astaxanthin as a novel...

Fed up: Probiotic research veteran issues global call to action

Fed up: Probiotic research veteran issues global call to action

Veteran probiotic researcher professor Gregor Reid is not a happy man. It’s time the...

Industry concerned about data abuse as EFSA fans transparency wings

Industry concerned about data abuse as EFSA fans transparency wings

Euros Jones

Director of regulatory affairs, European Crop Protection Association (ECPA)

Unilever: Healthier food choices must be ‘doable’

Unilever: Healthier food choices must be ‘doable’

Hans Zevenbergen

Cross-category nutrition and health director, Unilever

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

A new technology that utilises intestinal stem cells to grown mini gut structures in...

New technologies and academic collaborations will drive evidence and market growth for probiotics

New technologies and academic collaborations will drive evidence and market growth for probiotics

Greater collaboration from both within the industry, and between industry and academics, will help...

The data jungle: Matching gene content to probiotic traits could offer industry fresh hope

The data jungle: Matching gene content to probiotic traits could offer industry fresh hope

The probiotic industry is fighting several big fights at the minute, not least in...

Key Industry Events

 

Access all events listing

Our events, Events from partners...