SUBSCRIBE

Breaking News on Supplements & Nutrition - North AmericaEU edition

News > Suppliers

Read more breaking news

 

 

Study shows curcuminoids/piperine combo reduces knee osteoarthritis symptoms

Post a comment

By Hank Schultz

27-Aug-2014
Last updated on 27-Aug-2014 at 17:06 GMT

Study shows curcuminoids/piperine combo reduces knee osteoarthritis symptoms

Curcumin in combination with piperine is a safe and effective means of ameliorating the debilitating effects of knee osteoarthritis, according to a new study.

Conducted by researchers at Baqiyatallah University of Medical Sciences in Tehran, Iran, the study looked at various measures of knee discomfort.  The study used a curcumin ingredient supplied by Sabinsa Corp. that was also combined with piperine (an extract of black pepper) to boost bioavailability of this notoriously hard-to-absorb compound.  Sabinsa markets these ingredients under the brand names of Curcumin C3 Complex (a mixture of three curcuminoids) and Bioperine, respectively. The company also offered a decolorized Curcumin C3 Reduct version of the ingredient.

Study details

The randomized, placebo-controlled trial enrolled 40 subjects with mild to moderate knee osteoarthritis.  The 19-member curcuminoids group received 1500 mg of the curcuminoids/piperine treatment in three daily doses, while the 21-member control group got a matched placebo.  Measures of OA impairment used in the study were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS) and Lequesne's pain functional index (LPFI).  The test group showed statistically significant improvement in all scores, with the exception of the stiffness portion of the WOMAC score. No adverse effects were observed among the curcumin group.

“Curcuminoids represent an effective and safe alternative treatment for OA,” the authors concluded.

Mode of action

In a separate paper generated from the same trial , researchers looked at the systemic antioxidant effects of curcuminoids. They concluded these effects, which have been well established in other studies, could not account for the positive effects on knee osteoarthritis observed in this study.  So how did the curcuminoid treatment improve the measures for the test group?

The primary efficacy measures in osteoarthritis trials is reduction of disease symptoms and improvement of quality of life. We have shown that by assessing WOMAC, LPFI and VAS. This clearly supports the efficacy of curcuminoids,” said Amir Hosein Sahebkar, one of the study’s authors. “there are several factors in the pathophysiology of osteoarthritis. And we just looked at systemic inflammation.”

Sahebkar noted that parsing out how curcuminoids have their effects is a complex undertaking, as these molecules interact with more than 400 molecular targets.  in another paper that awaits peer review, the authors looked at the oxidative stress markers in these groups, and found that the curcuminoid/piperine combo reduced these biomarkers compared to placebo, which could account for the overall positive effects on knee osteoarthritis, Sahebkar said.

“There also other putative mechanisms: One is that curcuminoids may exert their anti-osteoarthritis effects through local anti-inflammatory properties rather than systemic effects. Hence, it would be nice to measure the biomarkers in the synovial fluid rather than in plasma. Another effect may be modulation of the immune system, as immune system deregulations may play a role in the pathogenesis of osteoarthritis. There are different potential mechanisms for the protetic effects of curcuminoids in osteoarthritis. We have looked at systemic inflammation and oxidative stress so far, and the second one has give positive results,” Sahebkar said.

Source: Phyotherapy Research
2014 May 22. doi: 10.1002/ptr.5174. [Epub ahead of print]
"Curcuminoid Treatement for Knee Osteoarthritis: A Randomized, Placebo-Controlled Trial"
Authors: Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A.

Post a comment

Comment title *
Your comment *
Your name *
Your email *

We will not publish your email on the site

I agree to Terms and Conditions

These comments have not been moderated. You are encouraged to participate with comments that are relevant to our news stories. You should not post comments that are abusive, threatening, defamatory, misleading or invasive of privacy. For the full terms and conditions for commenting see clause 7 of our Terms and Conditions ‘Participating in Online Communities’. These terms may be updated from time to time, so please read them before posting a comment. Any comment that violates these terms may be removed in its entirety as we do not edit comments. If you wish to complain about a comment please use the "REPORT ABUSE" button or contact the editors.

Related products