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Three months of consuming a daily supplement of resveratrol may help with blood sugar control and improve blood pressure in type-2 diabetics, suggests data from India.
Improvements in Hemoglobin A1C, a marker of the long-term presence of excess glucose in the blood, were observed following three months of supplementation with 250 milligrams per day of resveratrol (Biofort, Biotivia Bioceuticals International) in combination with oral hypoglycemic agents.
“The results of the present study support our hypothesis that resveratrol supplementation improves glycemic control and the associated risk factors in patients with type 2 diabetes mellitus,” wrote researchers in Nutrition Research .
“The study also suggests that resveratrol could be used as an effective adjuvant therapy with a conventional hypoglycemic regimen to treat type 2 diabetes mellitus.”
Resveratrol
Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption.
Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimer’s.
Study details
The researchers, led by Moola Joghee Nanjan from the JSS College of Pharmacy in Tamilnadu, India, sought to test their hypothesis that oral supplementation of resveratrol could improve the glycemic control in type-2 diabetics.
Sixty-two people were randomly assigned to receive their standard oral hypoglycemic agents with or without resveratrol (250 mg/d) for three months.
Results showed that average Hemoglobin A1C levels were 9.65 in the resveratrol group, compared to 9.99 in the control group. Systolic blood pressure was also significantly lower in the resveratrol group, compared to the control group: 127.92 versus 139.71 mmHg, respectively.
Significant improvements were also recorded in total cholesterol levels and total protein, said the researchers.
“To the best of our knowledge, this is the first clinical study to evaluate the effect of resveratrol as supplement in Indian patients with type-2 diabetes,” wrote the researchers. The potential mechanism behind the benefits is not clear, they added, and additional research is needed to elucidate the mechanism.
“Oral supplementation of resveratrol is thus found to be effective in improving glycemic control and may possibly provide a potential adjuvant for the treatment and management of diabetes,” they concluded.
Source: Nutrition Research
Published online ahead of print, doi: 10.1016/j.nutres.2012.06.003
“Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus”
Authors: J.K. Bhatt, S. Thomas, M.J. Nanjan
6 comments (Comments are now closed)
Resveratrol dosage
There was another human study with much lower resveratrol dose, which shows resveratrol increase insulin sensitivity. The very high dose of resveratrol is NOT a specific resveratrol effect, but a POLYPHENOL effect. Every poluphenol does this in this very high dosage.
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Posted by Laszlo G Meszaros
22 August 2012 | 09h09
Resveratrol and Diabetes
Resveratrol again proved its efficiency in Diabetes control. Biotivia LLC is manufacturing the best RSV products in market and same can be backed by its scientific studies.
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Posted by Dr Shah
10 August 2012 | 13h25
Reply to Ann
Hemoglobin levels are a tertiary measurement of diabetes remediation at best. You seem to have missed the point of the study. Glucose management and modulation of the destructive hypertension characteristic of diabetes patients are far more important than any attenuation of hemoglobin parameters. In this regard Bioforte performed extraordinarily well. Metformin alone will not normally achieve these good therapeutic results.
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Posted by Dr Gupta
09 August 2012 | 23h01
is the change significant?
In the reporter's summary, I do not see any explanation of the value of the difference in hemoglobin A1c between 9.9 and 9.6%. Both reflect extremely poor diabetes control. A change of 0.3% may not be meaningful in the health of these participants. Inclusion of the variation in A1c seen in both groups in response to the compound is required for any interpretation like "shows potential."
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Posted by ann ohlin
09 August 2012 | 18h26
Also used Biotivia RSV
This study also used Biotivia's RSV product, Bioforte and achieved even better results than the Albert Einstein study.
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Posted by Dr Gupta
09 August 2012 | 10h03
Diabetes and RSV
This study confirms the recently published one done by Albert Einstein Med College in which biotivia's transmax RSV enhanced insulin sensitivity, improved glucose tolerance, and improved mitochondrial function in pre diabetics.
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Posted by James Harrison
09 August 2012 | 07h59
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