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Resveratrol-rich grape extract shows heart health benefits: Human data

3 commentsBy Stephen Daniells , 26-Apr-2012

One year of supplementation with a resveratrol-containing grape extract decreased markers of inflammation and boosted heart health, says a new human study from Spain.

The trial, claimed to be “the longest human trial reported thus far using a resveratrol-containing product”, found that levels of C-reactive protein (CRP), a well-established marker of inflammation, fell by 26%, report researchers in the The American Journal of Cardiology .

The study was performed in people at high risk of cardiovascular disease (CVD) and the participants were also receiving statins. However, people in the placebo group did not exhibit the same beneficial reductions in inflammatory markers.

“We describe for the first time that a dietary intervention with a specific grape nutraceutical containing resveratrol 8 mg significantly improved the inflammatory and fibrinolytic status of patients undergoing primary prevention of CVD,” wrote researchers, led by Juan Carlos Espin, PhD, from the Research Group on Quality, Safety, and Bioactivity of Plant Foods, CEBAS-CSIC, Murcia.

Heart benefits

Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption.

Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimer’s.

Study details

The Spanish researchers recruited 75 people receiving statins as primary prevention of CVD to participate in their triple-blinded, randomized, parallel, dose-response, placebo-controlled, follow-up trial.

Participants received either a resveratrol-rich grape supplement (resveratrol 8 mg), a conventional resveratrol-free grape supplement resveratrol, or placebo (maltodextrin) for six months, and then double the dose for the next six months.

Results showed a significant decrease in CRP levels in the resveratrol-rich grape supplement only, with no changes in the other two groups. In addition, other markers of inflammation decreased, including tumor necrosis factor-alpha (TNF-alpha, 19.8% decrease), and plasminogen activator inhibitor type 1 (PAI-1, 16.8% decrease).

On the other hand, the resveratrol-rich grape supplement also increased levels of the anti-inflammatory interleukin-10 by 20%, while no such changes were observed in the other groups.

Inflammation and heart disease

“In the present trial, the decrease of CRP in group [resveratrol-rich grape supplement] was correlated with decreases in TNF-alpha and PAI-1 values, which are also important markers in the onset of [cardiovascular] events,” wrote the researchers.

“This is consistent with the known regulation of CRP by many inflammatory signals such as TNF-alpha, which alters vascular endothelium homeostasis, impairs fibrinolytic status by increasing PAI-1 levels, and induces plaque destabilization.”

“Despite the beneficial effects observed, the sample size and follow-up (1 year) prevented conclusions related to prediction of future CV events in these patients,” they concluded.

Source: The American Journal of Cardiology
Published online ahead of print, doi: 10.1016/j.amjcard.2012.03.030
“One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease”
Authors: J. Tomé-Carneiro, M. Gonzalvez, M. Larrosa, et al.

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3 comments (Comments are now closed)

Public funds

This work was supported by Projects CICYT-BFU2007-60576, Consolider
Ingenio 2010, CSD2007-00063 (Fun-C-Food) (Spanish Government),
and Fundación Séneca de la Region de Murcia (Grupo de Excelencia
GERM 06, 04486). Dr. Tomé-Carneiro received a FPI predoctoral grant
from the Spanish Ministry of Science and Innovation (MICINN), and Dr.
Larrosa received a JAE-DOC contract from the Consejo Superior de
Investigaciones Científicas (CSIC, Spain).

Report abuse

Posted by Mathias
10 May 2012 | 19h44

Was this part-funded by supplement makers?

I have reservations about any research on supplements funded or part-funded by any company that markets or has a financial interest in this or similar products. Is this research completely independent of commercial interests?

Report abuse

Posted by chris aylmer
09 May 2012 | 12h55

Congratulations!

Finally! So many resveratrol studies... and this is the first long-term trial in humans! Good!

Report abuse

Posted by jonathan
26 April 2012 | 22h24

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