Omega-3 DHA may boost male fertility: For mice at least

By Stephen Daniells

- Last updated on GMT

Related tags Omega-3 fatty acids Omega-3 fatty acid Essential fatty acid

Supplements of the omega-3 fatty acid DHA (docosahexaenoic acid) may reverse abnormalities in sperm associated with infertility, suggests a new study with mice.

Mice engineered to lack a gene that codes for an enzyme that helps them produce DHA were found to have fewer sperm and more abnormalities in what little sperm they did have, but such effects were reversed in mice fed DHA, researchers from the University of Illinois report in the Journal of Lipid Research​.

“It was very striking. When we fed the mice DHA, all these abnormalities were prevented,"​ said lead researcher Dr Manabu Nakamura.

If additional research backs up the animal data, it may see fertility added to the long list of potential benefits of omega-3 fatty acids, including improved heart health, cognitive function, mood and behaviour, eyes, joint health, and potentially reducing the risk of some kinds of cancer.

"We get hints from looking at sperm in the DHA-deficient animals about what type of pathology we may be looking at and why these polyunsaturated fatty acids are important. But we're still at the starting point in understanding the mechanisms that are involved, and we need to do more research at the cellular level," ​cautioned Nakamura.

Of mice and men

This is not the first time omega-3 fatty acids have been linked to sperm quality and fertility: An Iranian study reported earlier this year that infertile men have lower levels of omega-3 fatty acids in their sperm than fertile men. The study included 150 men and was published in the peer-reviewed journal Clinical Nutrition ​(February 2010, Vol. 29, pp. 100-105).

“These results suggest that research should be performed to assess the potential benefits of omega-3 fatty acid supplementation as a therapeutic approach in infertile men,”​ wrote the researchers, led by Mohammad Reza Safarinejad from Shahid Beheshti University in Tehran, Iran.

“To our knowledge, this is the first study evaluating the association of omega-3 and omega-6 fatty acids on semen quality, and seminal plasma anti-oxidant capacity in infertile and fertile men,”​ they added.

The findings are biologically plausible, noted the Iranian researchers, with DHA, for example, known to be present in the membranes of spermatozoa.

New data

For the mouse study, Nakamura and his co-workers engineered mice to lack a gene which codes for the delta-6-desaturase enzyme, which is involved in the transformation of the plant-source omega-3 alpha-linolenic acid (ALA). Without the enzyme the mice are unable to synthesise DHA.

“In the absence of DHA, male mice are basically infertile, producing few if any misshaped sperm that can't get where they need to go,”​ said Nakamura.

When mice were fed a diet supplements with 0.2 per cent DHA, however, the researchers noted that the fatty acid was capable of restoring all observed impairment in male reproduction”​.

The researchers confirmed that they would continue to investigate how omega-3s effect fertility. It may be some time before fish oils are recommended to help boost male fertility.

Source: Journal of Lipid Research
Volume 51, Pages 360-367
“Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice”
Authors: M. Roqueta-Rivera, C.K. Stroud, W.M. Haschek, S.J. Akare, M. Segre, R.S. Brush, M.-P. Agbaga, R.E. Anderson, R.A. Hess, M.T. Nakamura

Related news

Show more

Related products

show more

Nutriterra DHA Canola for Global Omega-3 Day

Nutriterra DHA Canola for Global Omega-3 Day

Content provided by Nuseed Nutritional | 28-Feb-2024 | Data Sheet

March 3 is Global Omega-3 Day. While almost everyone needs more omega-3, not everyone tolerates marine oil. Nutriterra DHA Canola makes it easy to celebrate...

Krill oil supports six key areas of healthy aging

Krill oil supports six key areas of healthy aging

Content provided by Aker BioMarine | 14-Feb-2024 | White Paper

The global population is getting older—according to WHO by 2050 the world’s population over 60 years will double and the population above 80 years will...

Consumers' growing demand for Omegas

Consumers' growing demand for Omegas

Content provided by Fruit d'Or | 13-Feb-2024 | White Paper

Consumers are increasingly interested in the benefits of omegas supplements. According to forecasts for 2023–2030, the global omega-3 market is expected...

Related suppliers

Follow us

Products

View more

Webinars