Breaking News on Supplements & Nutrition - North AmericaEU edition

News > Research

Loading...

New models hold promise for probiotic claim substantiation

By Nathan Gray+

29-Nov-2012

Exposing healthy people to modified pathogens in a controlled clinical trial setting could be an exciting new way for industry to overcome the challenges of health claim substantiation, says Nizo Food Research expert.

Probiotics have been a hot topic of late, with attempts to gain EFSA approved health claims causing a number of headaches for the sector.

However, Alwine Kardinaal, senior researcher for health and nutrition at Nizo Food Research believes new challenge models that expose healthy participants to modified versions of pathogens show great promise in elucidating the positive health effects of probiotics.

“EFSA does not accept that there are good or bad bacteria, but they do accept that claims should focus on resistance against pathogens,” explained Kardinaal. “The problem is that there are not very good markers for this.”  

“What is necessary to substantiate a claim in this area is to look at clinical symptoms caused by pathogens, and that is not an easy answer.”

“you need people to get infected”

Kardinaal said that one of the key challenges for industry is that they need to be able to show a positive effect in the target population for the product that will bear the claim – healthy people.

“That means that you need people to get infected,” she said. “There are a number of models that you can think of to do the trick.”

The Nizo expert said while models of spontaneous infection can work, in which people who may be more likely to become ill often are studied, there is an issue with the spontaneous nature of the infections that may occur.

“The problem with such studies is that you don’t know upfront who is going to get infected and who is not. So these typse of studies require quite a large number of study participants which makes them relatively expensive and complex.

A potential solution to this, she noted, is to perform what is essentially a randomised clinical trial by exposing healthy individuals to a pathogen in a controlled way.

“That is a model that we have used in a number of situations,” said Kardinaal. “It can be used to show effects on resistance against pathogens of probiotics, prebiotics, but other ingredients as well.”

Related products

Food Vision 2014: Bridge knowledge gaps, overcome change and work sustainably

Food Vision 2014: Bridge knowledge gaps, overcome change and work sustainably

What is the future of food? Simple communication of complex advances will be crucial,...

Innovation for today: Digital tech empowers industry to innovate

Chris Cornyn

founder & president, DINE Marketing

Global probiotic market to add 50% to €33bn by 2018: Analyst

Global probiotic market to add 50% to €33bn by 2018: Analyst

Ewa Hudson

Global head of health and wellness research , Euromonitor International

Pressurized water extraction technology promises greater yields

Pressurized water extraction technology promises greater yields

A new pressurized water exraction technology promises to get around some of the issues...

NDI trespassers continue to plague market, attorney says

NDI trespassers continue to plague market, attorney says

Follow on ingredients that rely on the safety halo provided by New Dietary Ingredient...

Protein has a big ‘ordinary’ future, says Glanbia

Protein has a big ‘ordinary’ future, says Glanbia

Carla Clissman

European commercial director, , Glanbia Nutritionals

Hiring an attorney early is cheaper than hiring one late, expert says

Hiring an attorney early is cheaper than hiring one late, expert says

As dietary supplement firms prepare for their initial (or follow up) GMP compliance inspections,...

UNPA chief agrees with FDA that GMP compliance far from uniform

UNPA chief agrees with FDA that GMP compliance far from uniform

Adverse event reporting, amphetamine-like substances showing up in products and NDI notifications are all...

Another BRIC in the weight management wall as sector hits $150bn globally in 2013

Another BRIC in the weight management wall as sector hits $150bn globally in 2013

Ewa Hudson

Global head of health and wellness research, Euromonitor International

Algatech: Functional food on astaxanthin horizon

Algatech: Functional food on astaxanthin horizon

Israeli firm Algatechnologies will work towards gaining approval for its astaxanthin as a novel...

Fed up: Probiotic research veteran issues global call to action

Fed up: Probiotic research veteran issues global call to action

Veteran probiotic researcher professor Gregor Reid is not a happy man. It’s time the...

Industry concerned about data abuse as EFSA fans transparency wings

Industry concerned about data abuse as EFSA fans transparency wings

Euros Jones

Director of regulatory affairs, European Crop Protection Association (ECPA)

Unilever: Healthier food choices must be ‘doable’

Unilever: Healthier food choices must be ‘doable’

Hans Zevenbergen

Cross-category nutrition and health director, Unilever

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

A new technology that utilises intestinal stem cells to grown mini gut structures in...

New technologies and academic collaborations will drive evidence and market growth for probiotics

New technologies and academic collaborations will drive evidence and market growth for probiotics

Greater collaboration from both within the industry, and between industry and academics, will help...

The data jungle: Matching gene content to probiotic traits could offer industry fresh hope

The data jungle: Matching gene content to probiotic traits could offer industry fresh hope

The probiotic industry is fighting several big fights at the minute, not least in...

Re-forming resveratrol: Bioavailability issues are no more as researchers reveal metabolites regenerate

Re-forming resveratrol: Bioavailability issues are no more as researchers reveal metabolites regenerate

Metabolites from the break-down of resveratrol have been shown to come together and regenerate...

Key Industry Events

 

Access all events listing

Our events, Events from partners...