SUBSCRIBE

Breaking News on Supplements & Nutrition - North AmericaEU edition

News > Research

Read more breaking news

 

 

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

By Nathan Gray+

20-Feb-2013
Last updated on 20-Feb-2013 at 15:38 GMT2013-02-20T15:38:46Z

‘Mini gut’ technology to make probiotic research efficient and cheaper
‘Mini gut’ technology to make probiotic research efficient and cheaper
Loading...

A new technology that utilises intestinal stem cells to grown mini gut structures in the lab promises to help probiotic researchers achieve efficient and cost effective research, according to TNO.

The ‘mini guts’ – known as organoids – are fully functioning gut tissues that can be used by researchers to efficiently test the effect of dietary interventions on gut physiology and cellular signalling factors.

Speaking with NutraIngredients Sabina Lukovac of TNO Research in the Netherlands explained that the small gut structures can be grown in the lab from intestinal stem cells using specialised growth media and techniques.

“What we do is manipulate intestinal stem cells … in a way that we can make them self-renew, and grow into normal functional gut epithelial cells” said Lukovac.  “We can do this actually for different species.”

The researcher added that the original research was done on mouse gut cells, while TNO is now examining organoids different species – and is currently growing pig intestine organoids.

Screening platform

“The whole gut organoid system was set up to serve for regenerative medicine, so the innovative thing about TNO is that we want to use it for a totally different purpose,” said the innovation scientist.

“We want to use it as a screening platform,” she said, explaining that the system will be able to test food components such as probiotics, specific nutrients, and drugs. “There is a huge area of applications that you can think of, but right now we are focusing on probiotics.”

“It’s really physiologically relevant, so it doesn’t just represent one cell from the intestine, it represents the whole,” said Lukovac. “All the cells actually secrete hormones, they secrete antimicrobial peptides, so it’s really better than the existing in vitro system and it’s cheaper as well.” 

Related products

African probiotic project reaching 10,000 infants a day

African probiotic project reaching 10,000 infants a day

Professor Gregor Reid

Chair , University of Western Ontario & Human Microbiology and...

UK researcher backs supplements for omega-3 intakes

UK researcher backs supplements for boosting omega-3 intakes

Philip Calder

Professor, University of Southamption

‘You think Red Bull’s just gonna roll over? It’s not gonna happen!’

‘You think Red Bull’s just gonna roll over? It’s not gonna happen!’ Expert warns wannabes

Beverage brand development guru James Tonkin has warned wannabe entrepreneurs that going up against...

Coffee may hydrate athletes just like water: Researcher

Coffee may hydrate athletes just like water: Researcher

Sophie Killer

Doctoral researcher, Loughborough University

Caffeine in small doses and during training may boost performance

Caffeine taken during training and even in small doses may boost sports performance: Researcher

Sophie Killer

Doctoral researcher in exercise metabolism and performance nutrition

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Professor John Cryan

Chair and head of the Department of Anatomy and Neuroscience,...

Algatech: Functional food on astaxanthin horizon

Algatech: Functional food on astaxanthin horizon

Israeli firm Algatechnologies will work towards gaining approval for its astaxanthin as a novel...

Fed up: Probiotic research veteran issues global call to action

Fed up: Probiotic research veteran issues global call to action

Veteran probiotic researcher professor Gregor Reid is not a happy man. It’s time the...

Industry concerned about data abuse as EFSA fans transparency wings

Industry concerned about data abuse as EFSA fans transparency wings

Euros Jones

Director of regulatory affairs, European Crop Protection Association (ECPA)

The making of a brand: Contract manufacturers share secrets to success

The making of a brand: Contract manufacturers share secrets to success

The firms that manufacture healthy food and supplement products do much more than just...

The ins and outs: Are firms shifting to vertically integrated supply chains?

The ins and outs: Are firms shifting to vertically integrated supply chains?

Outsourcing. It's no secret it can bring big financial and logistical gains. But in...

Outsourcing science: Where does the future of industry research lie?

Outsourcing science: Where does the future of industry research lie?

An trend for outsourcing science and research may be good news for contract research...

How has social media changed food marketing?

How has social media changed food marketing?

The rise of social media has led to a shift in the way consumers...

Is personalised nutrition about to go public in a big way?

Is personalised nutrition about to go public in a big way?

Radek Sali, CEO,Swisse Wellness;

François Scheffler, head, BASF human nutrition;, Loren Israelsen, president, United...

Alkemist Labs CEO: We need transparency among the analytical labs

Alkemist Labs CEO: We need transparency among the analytical labs

The analytical community should embrace transparency to then allow manufacturers to share that with...

NOW Foods’ Secrist on the need for greater transparency and why brokers are ‘the bane of the industry’

NOW Foods’ Secrist on the need for greater transparency and why brokers are ‘the bane of the industry’

The recent NY AG probe has kick-started some industry organizations to say self-policing needs...

Qualitas says drawbacks of open pond algae cultivation easily dealt with

Qualitas says drawbacks of open pond algae cultivation easily dealt with

Qualitas Health, a supplier of a unique polar-lipid structured algal omega-3 ingredient, is now...

Mazza Innovation nears full scale production with innovative water extraction process

Mazza Innovation nears full scale production with innovative water extraction process

Mazza Innovation, a producer of botanical extracts, has moved beyond the proof of concept...

Cargill's Viatech platform deconstructs stevia leaf to identify better blends

Cargill's Viatech platform deconstructs stevia leaf to identify better blends

Cargill is “all in on stevia,” according to Scott Fabro, global business development director. ...