Breaking News on Supplements & Nutrition - North AmericaEU edition

News > Research

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

By Nathan Gray+

20-Feb-2013
Last updated the 20-Feb-2013 at 15:38 GMT

‘Mini gut’ technology to make probiotic research efficient and cheaper
‘Mini gut’ technology to make probiotic research efficient and cheaper
Loading...

A new technology that utilises intestinal stem cells to grown mini gut structures in the lab promises to help probiotic researchers achieve efficient and cost effective research, according to TNO.

The ‘mini guts’ – known as organoids – are fully functioning gut tissues that can be used by researchers to efficiently test the effect of dietary interventions on gut physiology and cellular signalling factors.

Speaking with NutraIngredients Sabina Lukovac of TNO Research in the Netherlands explained that the small gut structures can be grown in the lab from intestinal stem cells using specialised growth media and techniques.

“What we do is manipulate intestinal stem cells … in a way that we can make them self-renew, and grow into normal functional gut epithelial cells” said Lukovac.  “We can do this actually for different species.”

The researcher added that the original research was done on mouse gut cells, while TNO is now examining organoids different species – and is currently growing pig intestine organoids.

Screening platform

“The whole gut organoid system was set up to serve for regenerative medicine, so the innovative thing about TNO is that we want to use it for a totally different purpose,” said the innovation scientist.

“We want to use it as a screening platform,” she said, explaining that the system will be able to test food components such as probiotics, specific nutrients, and drugs. “There is a huge area of applications that you can think of, but right now we are focusing on probiotics.”

“It’s really physiologically relevant, so it doesn’t just represent one cell from the intestine, it represents the whole,” said Lukovac. “All the cells actually secrete hormones, they secrete antimicrobial peptides, so it’s really better than the existing in vitro system and it’s cheaper as well.” 

Related products

Caffeine in small doses and during training may boost performance

Caffeine taken during training and even in small doses may boost sports performance: Researcher

Sophie Killer

Doctoral researcher in exercise metabolism and performance nutrition

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Psychobiotics can feed gut-brain health axis: 'It’s really an exciting frontier,' says professor

Professor John Cryan

Chair and head of the Department of Anatomy and Neuroscience,...

Algatech: Functional food on astaxanthin horizon

Algatech: Functional food on astaxanthin horizon

Israeli firm Algatechnologies will work towards gaining approval for its astaxanthin as a novel...

Fed up: Probiotic research veteran issues global call to action

Fed up: Probiotic research veteran issues global call to action

Veteran probiotic researcher professor Gregor Reid is not a happy man. It’s time the...

Industry concerned about data abuse as EFSA fans transparency wings

Industry concerned about data abuse as EFSA fans transparency wings

Euros Jones

Director of regulatory affairs, European Crop Protection Association (ECPA)

Unilever: Healthier food choices must be ‘doable’

Unilever: Healthier food choices must be ‘doable’

Hans Zevenbergen

Cross-category nutrition and health director, Unilever

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

A new technology that utilises intestinal stem cells to grown mini gut structures in...

New technologies and academic collaborations will drive evidence and market growth for probiotics

New technologies and academic collaborations will drive evidence and market growth for probiotics

Greater collaboration from both within the industry, and between industry and academics, will help...

Cargill rides publicity wave with Trehalose functional ingredient

Cargill rides publicity wave with Trehalose functional ingredient

Cargill has weathered a potential media storm concerning its functional ingredient Trehalose.  The ingredient,...

Particulars of GRAS process leave it open to criticism, expert says

Particulars of GRAS process leave it open to criticism, expert says

The GRAS process as it stands in the United States is vulnerable to criticism...

Video: In light of FDA's reticence, professional help critical in NDI submissions

Video: In light of FDA's reticence, professional help critical in NDI submissions

The submissions of New Dietary Ingredient notifications seems as fraught as ever, and part...

Keeping it clean: 3 botanical chiefs pull adulteration weeds

Keeping it clean: 3 botanical chiefs pull adulteration weeds

Antoine Bily, Naturex global R&D director

Christian Artaria, Indena marketing director, Holger Riemensperger, Frutarom general manager,...

Diet and cancer: Polyphenol trial data suggests significant clinical benefit for prostate cancer

Diet and cancer: Polyphenol trial data suggests significant clinical benefit for prostate cancer

Professor Robert Thomas

Consultant oncologist, Addenbrooke's and Bedford, Cambridge University Hospital

Are doctors seeing the preventative eye health potential of carotenoids?

Are doctors seeing the preventative eye health potential of carotenoids?

James Stringham

Research doctor, University of Georgia

Natural and synthetic astaxanthin are different products, Algatech exec says

Natural and synthetic astaxanthin are different products, Algatech exec says

The natural vs synthetic astaxanthin debate centers on the fact that the products are...

Key Industry Events

 

Access all events listing

Our events, Events from partners...