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Earlier the better for omega-3 benefits for brains & hearts?

2 commentsBy Stephen Daniells , 04-Jul-2011
Last updated on 05-Jul-2011 at 15:03 GMT

Earlier the better for omega-3 benefits for brains & hearts?

Supplements of omega-3 fatty acids for brain and heart health may need to be provided early in life to produce any benefits, suggests a new study with rats.

Four months of feeding omega-3s to old rats did not affect age-related declines in cognitive function, but the supplements did produce some “small but positive” changes to heart function, according to findings published in the Journal of Gerontology: Biological Science .

Researchers from Wake Forest University School of Medicine and University of South Dakota said that their observations “data raise the possibility that fish oil supplementation for purposes of cardiac and brain protection may need to occur earlier in the life span”.

Heart health

The heart health benefits of fish oil, and the omega-3 fatty acids it contains, are well-documented, being first reported in the early 1970s by Dr Jorn Dyerberg and his co-workers in The Lancet and The American Journal of Clinical Nutrition. To date, the polyunsaturated fatty acids (PUFAs) have been linked to improvements in blood lipid levels, a reduced tendency of thrombosis, blood pressure and heart rate improvements, and improved vascular function.

“From a therapeutic perspective, it is not known if efficacious dosages of omega-3 [polyunsaturated fatty acids, or PUFAs] that improve cardiac function in aging would also be effective for improving brain function,” explained the researchers, led by Wake Forest’s Leanne Groban, MD.

“The current study was designed to explore the effects of a dietary intervention on both brain and cardiac function in the same subject using a well-established model of cognitive decline in aging,” they added.

Study details

Dr Groban and her co-workers used young and older male rats and fed them a standard diet for five or 24 months, respectively. After this time the animals were switched to an experimental diet containing approximately 1.75 mg EPA and 1.17 mg DHA per day per animal for one or four months, respectively. At the end of this period all animals were subjected to a range or tests to assess cardiovascular and cognitive function.

Results showed that the older animals did benefit from fish oil supplementation, but the benefits were limited to diastolic function, or the filling of the heart with blood following contraction (systolic).

The younger animals had better spatial memory than the older animals, and the fish oil supplements were not associated with any reversal of the age-related memory deficits or increases in inflammation in the brain, wrote the researchers.

“Future studies are needed to address the hypothesis that supplementation may need to occur prior to the accumulation of inflammatory damage to be effective in brain, and almost certainly in the heart,” they wrote.

“If the hypothesis were proven correct, it would indicate that supplementation is beneficial when used preventatively but ineffective at reversing damage if begun late in the life span after chronic inflammation has been established.”

Source: Journal of Gerontology: Biological Science
2011; Volume 66A, Issue 5, Pages 521-533, doi:10.1093/gerona/glr017
“Dietary Fish Oil Modestly Attenuates the Effect of Age on Diastolic Function but Has No Effect on Memory or Brain Inflammation in Aged Rats”
Authors: S. Sergeant, J.A. McQuail, D.R. Riddle, F.H. Chilton, S.B. Ortmeier, J.A. Jessup, L. Groban, M.M. Nicolle

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2 comments (Comments are now closed)

Omega-3 Supplement or Medicine HK 25.7.2011

Dr Lewis is so right, but the crux maybe that if a practitioner verus and MD recommended 7gms. of Omega-3 it would not longer be considered a supplement, but called medicine? So supplement manufacturers and retailers are stuck with the EU and Big Pharma looking over their shoulders. BUT, I suspect that if the Pharm Ind. were given sole supplier rights then the MD's would look at things differently. There's a lot of things similar e.g. Vitamin C dosages for various conditions. The EU et al seem not to want people self-medicating themselves OTC or knocking drug's out of Medicine's 50% risk and 'prescribed' profits sphere.It's a difficult time for supplements and Nat./Comp. Medicine in general.

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Posted by Helen Knowles
25 July 2011 | 13h29

Way underdosing m-3s

Using 3mg EPA/DHA in a 300 gram rat is 10mg/kg or 700 mg in a 70-kg person. Any study that is talking of using mg doses for treatment is completely underestimating the amount required to make a difference in treatment. While 700 mg may be good for general heath supplementation, there is a major difference between nutritional supplementation and treatment doses - by a log scale. Add another 0 to make it 7000mg/day in a 70-kg person and you will see therapeutic differences.

Again, nutritional supplementation and treatment with omega-3s are two very different things and doctors and scientists don't seem to grasp that difference.

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Posted by Michael Lewis, MD, MPH, MBA, FACPM
05 July 2011 | 16h07

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