Polyphenol blend shows metabolic and ‘quality of life’ improvements

Related tags Nutrition Clinical trial

Daily supplementation with a blend of polyphenol-rich extracts from grapefruit, grape, green tea, guarana and black carrot may boost metabolic functions, says a new study using Fytexia’s Fiit-ns branded ingredient.

Results of the 12-week randomized, double-blind, placebo-controlled clinical study indicated that a daily 0.9 gram dose of the polyphenol blend was associated with significant reductions in markers of inflammation (C-reactive protein) of 61%, and oxidative stress (malondialdehyde or MDA) of 34%, compared with placebo.

Significant improvements were observed for weight loss, reported the company, with participants in the intervention group reporting an average reduction of 6.1 kg more than the placebo group.

The study’s findings are in press in the International Journal of Food Sciences and Nutrition.

‘Synergistic blend’

Beziers, France-based Fytexia launched Fiit-ns in 2011, and positioned towards sports nutrition products. The ingredient is a combination of selected fruit & vegetable extracts and vitamin B3. Fytexia is now promoting the ingredient as a ‘metabolic anti-aging ingredient’.

The new study is the first clinical trial conducted with the ingredient. It was performed in collaboration with the Association Nationale de Prévention des Maladies in Paris, France, and involved 17 obese subjects aged between 39 and 44.

The participants were randomly assigned to receive either placebo or 2 capsules of Fiit-ns of 450 mg per day for 12 weeks. All participants were asked to continue to consume their normal diet and perform 30minutes per week of physical activity.

Results showed that, in addition to the improvements in CRP and MDA, the active intervention was associated with significant improvement in triglycerides (14% decrease) and glycated hemoglobin (14% decrease).

Hip size also decreased more in the active intervention group, compared to placebo, said the researchers.

Subjective measures such as energy rating and ‘well-being’ also improved in the Fiit-ns group, they added.

“With the publication of this clinical study, Fytexia demonstrates that Fiit-ns delivers benefits from the synergistic combination of selected fruit & vegetable extracts and vitamin B3 to improve quality of life based on the rejuvenation of metabolic functions,” said the company.

Source: International Journal of Food Sciences and Nutrition
In press
Authors: J. Cases, et al.